3-Hydroxy agomelatine NEW
| Price | $58 |
| Package | 1mg |
| Supply Ability: | 10g |
| Update Time: | 2026-05-22 |
Product Details
| Product Name: 3-Hydroxy agomelatine | CAS No.: 166526-99-4 |
| Purity: 99.97% | Supply Ability: 10g |
| Release date: 2026/05/22 |
Product Introduction
Bioactivity
| Name | 3-Hydroxy agomelatine |
| Description | 3-Hydroxy agomelatine (3-Hydroxyagomelatine) is a 5-HT2C receptor antagonist used in the study of neurological disorders. |
| In vitro | Agomelatine and S 21517 have relatively strong affinity for 5-HT2C receptors, with Ki values of 0.21 μM and 0.13 μM, respectively, while their metabolite 3-Hydroxy agomelatine has a lower affinity, with a Ki value of 1.8 μM, which is about 10-fold lower than that of the former two. All three are antagonists at the 5-HT2C receptor, and the order of potency is S 21517 > agomelatine > 3-Hydroxy agomelatine. [1] |
| In vivo | In Wistar rats, 3-Hydroxy agomelatine, administered by intraperitoneal injection at doses ranging from 1.25 to 40 mg/kg, did not significantly affect penile erections induced by mCPP and Ro 60-0175. [1] |
| Storage | Keep away from direct sunlight,Keep away from moisture Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 200 mg/mL (771.31 mM), Sonication is recommended. 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 5 mg/mL (19.28 mM), Sonication is recommended. H2O : 80 mg/mL (308.52 mM), Sonication is recommended. |
| Keywords | 5HTReceptor | 5-HT2C Receptor | 5HT Receptor | 3-Hydroxy agomelatine | 3Hydroxy agomelatine | 3 Hydroxy agomelatine |
| Inhibitors Related | Alverine citrate | Sevoflurane | Dapoxetine hydrochloride | Cefaclor monohydrate | Clozapine N-Oxide | 1,8-Cineole | Dopamine hydrochloride | Cloperastine hydrochloride | Mianserin hydrochloride | Trazodone hydrochloride | Cinchonidine | Doxepin hydrochloride |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, Massachusetts, USA
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