8-Methoxypsoralen
| Price | $1 |
| Package | 1KG |
| Min. Order: | 1G |
| Supply Ability: | 100KG |
| Update Time: | 2019-07-06 |
Product Details
| Product Name: 8-Methoxypsoralen | CAS No.: 298-81-7 |
| Min. Order: 1G | Purity: 98% |
| Supply Ability: 100KG | Release date: 2019/07/06 |
AD68
| 8-Methoxypsoralen Basic information |
| Description References |
| Product Name: | 8-Methoxypsoralen |
| Synonyms: | 2-g)(1)benzopyran-7-one,9-methoxy-7h-furo(;2-g][1]benzopyran-7-one,9-methoxy-7h-furo[;5-Benzofuranacrylic acid, 6-hydroxy-7-methoxy-, delta-lactone;5-Benzofuranacrylicacid,6-hydroxy-7-methoxy-,δ-lactone;6-Hydroxy-7-methoxy-5-benzofuranacrylic acid gamma-lactone;6-hydroxy-7-methoxy-5-benzofuranacrylicaciddelta-lactone;6-hydroxy-7-methoxy-5-benzofuranacrylicacidelta-lactone;7-Furocoumarin |
| CAS: | 298-81-7 |
| MF: | C12H8O4 |
| MW: | 216.19 |
| EINECS: | 206-066-9 |
| Product Categories: | Intermediates & Fine Chemicals;Pharmaceuticals;Cytochrome P450 isozyme;This product is manufactured in GMP workshop.;Aromatics;Heterocycles;API;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;OXSORALENE;Other APIs;Inhibitors |
| Mol File: | 298-81-7.mol |
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| 8-Methoxypsoralen Chemical Properties |
| Melting point | 148-150 °C(lit.) |
| Boiling point | 276.6°C (rough estimate) |
| density | 1.1344 (rough estimate) |
| refractive index | 1.4270 (estimate) |
| storage temp. | -20°C Freezer, Under Inert Atmosphere |
| solubility | H2O: slightly soluble |
| form | Needle-Like Crystals or Powder |
| color | white to yellow |
| Water Solubility | PRACTICALLY INSOLUBLE |
| Merck | 14,5988 |
| BRN | 196453 |
| CAS DataBase Reference | 298-81-7(CAS DataBase Reference) |
| NIST Chemistry Reference | Methoxsalen(298-81-7) |
| EPA Substance Registry System | 7H-Furo[3,2-g][1] benzopyran-7-one, 9-methoxy-(298-81-7) |
| Safety Information |
| Hazard Codes | Xn,T |
| Risk Statements | 22-43-46-45-34 |
| Safety Statements | 36/37-53-45-36/37/39-26 |
| RIDADR | 3216 |
| WGK Germany | 3 |
| RTECS | LV1400000 |
| F | 10 |
| TSCA | Yes |
| Hazardous Substances Data | 298-81-7(Hazardous Substances Data) |
| Toxicity | LD50 i.p. in rats: 470 ±30 mg/kg (Hakim) |
| 8-Methoxypsoralen Usage And Synthesis |
| Description | 8-methoxypsoralen (also known as methoxsalen) is a naturally occurring furocoumarin compound existing in several species of plants such as Psoralea corylifolia. It is a photoactive substance that can form DNA adducts upon UVA irradiation. It is a drug used for the treatment of psoriasis, eczema, vitiligo, and some kinds of cutaneous lymphomas associated with the exposure of skin to the UVA or light from lamps or sunlight. Its mechanism of action is through inhibiting the synthesis of the deoxyribonucleic acid (DNA). After the activation, it can preferentially bind to the guanine and cytosine molecules of DNA, further leading to the cross-linking of DNA, thus inhibiting the DNA synthesis. It can further inhibit the RNA and protein synthesis at high concentration. It is extracted from Ammi majus. |
| Chemical Properties | Crystalline Solid |
| Uses | antipsoriatic, pigmentation agent |
| Uses | Naturally occurring analog of Psoralen (P839800). Use in treatment of psoriasis and mycosis fungoides. |
| Uses | For the treatment of psoriasis and vitiligo |
| Uses | Naturally occurring analog of psoralen. Use in treatment of psoriasis and mycosis fungoides |
| Uses | A potent suicide inhibitor of cytochrome P-450. |
| Definition | ChEBI: A member of the class of psoralens that is 7H-furo[3,2-g]chromen-7-one in which the 9 position is substituted by a methoxy group. It is a constituent of the fruits of Ammi majus. Like other psoralens, trioxsalen causes photosensitization of the skin. It is administered topically or orally in conjunction with UV-A for phototherapy treatment of vitiligo and severe psoriasis. |
| General Description | Odorless white to cream-colored crystalline solid. Bitter taste followed by tingling sensation. |
| Air & Water Reactions | Sensitive to light and air. Insoluble in water. |
| Reactivity Profile | 8-Methoxypsoralen is incompatible with strong oxidizing agents. |
| Fire Hazard | Flash point data for 8-Methoxypsoralen are not available; however, 8-Methoxypsoralen is probably combustible. |
Company Profile Introduction
Established in 2014,Career Henan Chemical Co. is a manufacturerspecializing in the sale of fine chemicals.
Mainly deals in the sales of:
Pharmaceutical intermediates
OLED intermediates：
Pharmaceutical intermediates;
OLED intermediates;
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China- Since: 2014-12-17
- Address: Zhengzhou High tech Zone, Henan Province, China
INQUIRY
楊俊青
sales@coreychem.com
sales@coreychem.com