Product Details
| Product Name:
48740 RP |
CAS No.:
93363-11-2 |
| Purity:
99.79% |
Supply Ability:
10g |
| Release date:
2026/05/15 |
Product Introduction
Bioactivity
| Name | 48740 RP |
| Description | 48740 RP (RP 55779, (Rac)-RP-55778) belongs to synthetic compounds and is a platelet-activating factor (PAF) receptor antagonist with anti-inflammatory activity. This compound can be used in inflammation-related research, exerting its pharmacological effects through inhibition of the PAF/PAFR signaling pathway. |
| In vivo | Methods: The in vivo activity of 48740 RP was evaluated in Wistar rats: acute toxicity was assessed using the OECD up-and-down method with single oral and intraperitoneal administration, with observation for 14 days.
Results: Oral LD?? >2000 mg/kg, intraperitoneal LD?? >1098 mg/kg; pharmacokinetics were evaluated following single intravenous (50 mg/kg), oral (50 mg/kg), and intraperitoneal (75 mg/kg) administration, with oral time to peak of 33 min and bioavailability of approximately 77%. [1] |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 127.5 mg/mL (519.77 mM), Sonication is recommended.
|
| Keywords | RP-55779 | RP55779 | RP55778 | RP48740 | RP 48740 | Plateletaggregation | platelet-activating factor (PAF) | Platelet aggregation | 48740 RP |
| Inhibitors Related | Cedrol | Quinine | 3',4'-Dihydroxyacetophenone | PAF C-18 | 4(3H)-Quinazolinone | Carbasalate calcium | Nattokinase | Benzcyclane | Rocepafant | 2-Acetylbenzoic acid | P2Y1/P2Y12 antagonist-1 | Dersalazine |
| Related Compound Libraries | Bioactive Compound Library | Membrane Protein-targeted Compound Library | ReFRAME Related Library | Inhibitor Library | Bioactive Compounds Library Max | GPCR Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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