Dynasore Basic information

Product Name:

Dynasore

Synonyms:

304448-55-3;3-Hydroxy-naphthalene-2-carboxylic acid (3,4-dihydroxy-benzylidene)-hydrazide monohydrate;Dynasore monohydrate;Dynasore;3-Hydroxynaphthalene-2-carboxylicacid(3,4-dihydroxybenzylidene)hydrazide;3-Hydroxy-2-naphthalenecarboxylic acid [(3,4-dihydroxyphenyl)Methylene]hydrazide;2-Naphthalenecarboxylic acid, 3-hydroxy-, 2-[(3,4-dihydroxyphenyl)methylene]hydrazide;3-Hydroxy-2-naphthalenecarboxylic acid [(3,4-dihydroxyphenyl)methylene]hydrazide Dynasore

CAS:

MF:

C18H14N2O4H2O

MW:

0

EINECS:

 

Product Categories:

Signalling;Cell Cycle Regulation;Inhibitors

Mol File:

304448-55-3.mol

 

Dynasore Chemical Properties

storage temp. 

−20°C

form 

Off-white solid.

 

Safety Information

Hazard Codes 

N

Risk Statements 

50

Safety Statements 

22-24/25-61

RIDADR 

UN 3077 9/PG 3

MSDS Information

 

Dynasore Usage And Synthesis

Uses

Dynasore is a cell-permeable, reversible inhibitor of dynamin 1, dynamin 2, and mitochondrial dynamin, Drp1 GTPase activity (IC50 = 15 μM). Through this action, dynasore inhibits clathrin-dependent vesicle formation and endocytosis, which is necessary for internalization of certain parasites and viruses, as well as particles and receptor ligands. In some cases, dynasore can also augment the release of neurotransmitters and secreted cytokines.[Cayman Chemical]

Definition

ChEBI: A carbohydrazide resulting from the formal condensation of the hydrazone moiety of 3,4-dihydroxybenzaldehyde hydrazone with the carboxy group of 3-hydroxy-2-naphthoic acid. It is a cell-permeable, reversible noncompetitive inhibitor of the GTPase activity f dynamin 1 and 2 and Drp1 (mitochondrial), while exhibiting no significant effect against two other small GTPases, MxA and Cdc42.

Biological Activity

Non-competitive inhibitor of dynamin 1, dynamin 2 and mitochondrial dynamin (Drp1) GTPase activity. Does not inhibit other small GTPases. Blocks endocytic pathways dependent on dynamin and inhibits cell spreading and migration of BSC1 cells