Dynasore NEW
| Price | $45 | $72 | $143 |
| Package | 5mg | 10mg | 25mg |
| Supply Ability: | 10g |
| Update Time: | 2026-05-26 |
Product Details
| Product Name: Dynasore | CAS No.: 304448-55-3 |
| Purity: 95.85% | Supply Ability: 10g |
| Release date: 2026/05/26 |
Product Introduction
Bioactivity
| Name | Dynasore |
| Description | Dynasore (Dynamin Inhibitor I) is a highly selective, reversible small-molecule dynamin inhibitor with an IC?? of 15 μM. Dynasore also inhibits the mitochondrial dynamin Drp1 without affecting other small GTPases. By inhibiting the GTPase activity of dynamin, Dynasore blocks its function in membrane fission, thereby inhibiting clathrin-mediated endocytosis. Dynasore can be used in research on endocytosis, membrane transport, viral entry, and receptor signaling regulation. |
| Cell Research | Mouse ventricular myocytes are isolated from male adult C6/Black mouse. Cardiomyocytes subjects to 2 hours of drug treatment followed by oxidative stress (30 μM Water2 for 35 min). For ATP supplement experiments, the cells are treated with 3 mM ATP for 30 min before exposure to Water2. Cardiomyocyte survival and viability are analyzed by trypan blue exclusion (TBE) assay[3]. |
| Kinase Assay | RIP1 kinase assay: Phosphorylation of RIP1 requires its kinase activity. Expression constructs of FLAGtagged wild-type (WT) or a kinase-inactive point mutant of RIP1 (K45M) are are transfected into 293T cells and RIP1 kinase assay is performed as described in the Methods in the presence of [γ-32P]ATP for 30 min at 30℃. Samples are subjected to SDS-PAGE and RIP1 band is visualized by autoradiography. Relative intensities of radioactive bands are quantified and are shown (ratio) in this and all other autoradiographs. In parallel to kinase reactions, a sample of beads is subjected to western blot analysis using anti-RIP1 antibody to ensure equal protein amounts in kinase reactions. |
| In vitro | Methods: Mouse bone marrow-derived macrophages were pretreated with 5, 10, 25, or 50 μM Dynasore for 1 hour, then stimulated with 100 ng/mL LPS for 24 hours. Supernatants and cell lysates were collected. Pro-inflammatory cytokine expression levels were detected by real-time quantitative PCR. Results: Dynasore dose-dependently inhibited LPS-induced mRNA and protein levels of proinflammatory cytokines (TNF-α, IL-6, IL-12). [1] Methods: HCLE cells (Fluo-4 loaded) were pretreated with 40 μM Dynasore or 1 μM YM-58483 for 30 min, followed by induction of oxidative stress with 1 mM tBHP. Cytoplasmic calcium changes were monitored in real-time via fluorescence intensity over 2 hours. Results: Dynasore completely blocked tBHP-induced increases in cytoplasmic calcium. [2] Methods: Horizontal brainstem slices containing the solitary tract and solitary tract nucleus were prepared from adult rats. Whole-cell patch-clamp recordings were performed on NTS neurons at a clamp voltage of -60 mV. 100 μM Dynasore dissolved in artificial cerebrospinal fluid was continuously administered via a perfusion system. Postsynaptic currents were recorded at different time points (pre-administration, during administration, post-washout). Results: Dynasore rapidly increased the frequency of spontaneous excitatory postsynaptic currents (EPSCs). Concurrently, ST-evoked EPSCs progressively failed until completely blocked, with no reversal during the recovery period.[3] |
| In vivo | Methods: An acute lung injury (ALI) model was established in C57BL/6J mice via intratracheal LPS (10 mg/kg) administration. Dynasore (10, 30, 50 mg/kg) was administered as a single intraperitoneal injection 3 hours prior to LPS challenge. Mice were euthanized 24 hours after LPS stimulation. Results: Dynasore pretreatment (particularly at 30 and 50 mg/kg) significantly reduced lung tissue histopathology scores and decreased inflammatory mediators. [1] |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | Ethanol : 1.6 mg/mL (4.96 mM), Sonication is recommended. DMSO : 120 mg/mL (372.31 mM), Sonication is recommended. 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 4 mg/mL (12.41 mM), Sonication is recommended. |
| Keywords | VirusProtease | Virus Protease | Inhibitor | inhibit | HSV | Herpes simplex virus | Dynasore | Dynamin1/2 | Dynamin | Autophagy |
| Inhibitors Related | Stavudine | Aceglutamide | Hemin | Tamoxifen | Cysteamine hydrochloride | Guanidine hydrochloride | Hydroxychloroquine | Paeonol | Thymidine | Naringin | Alginic acid | Sildenafil citrate |
| Related Compound Libraries | Highly Selective Inhibitor Library | Bioactive Compound Library | Autophagy Compound Library | Protease Inhibitor Library | Anti-Viral Compound Library | Inhibitor Library | Mitochondria-Targeted Compound Library | Anti-Aging Compound Library | Bioactive Compounds Library Max | Cytoskeletal Signaling Pathway Compound Library | Anti-Infection Compound Library | Human Metabolite Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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