CK-636 Basic information

Description In vitro

Product Name:

CK-636

Synonyms:

CK-636;N-[2-(2-Methyl-1H-indol-3-yl)ethyl]-2-thiophenecarboxamide;CK-0944636;CK-636 N-[2-(2-Methyl-1H-indol-3-yl)ethyl]-2-thiophenecarboxamide;N-[2-(2-Methyl-1H-indol-3-yl)ethyl]-2-thiophenecarboxamide CK636;CK-636, >=98%;CK-636(CK-0944636;442632-72-6

CAS:

MF:

C16H16N2OS

MW:

284.37604

EINECS:

 

Product Categories:

Inhibitors

Mol File:

442632-72-6.mol

 

CK-636 Chemical Properties

storage temp. 

2-8°C

solubility 

DMSO: ≥20mg/mL

form 

powder

color 

peach to light tan

InChIKey

ACAKNPKRLPMONU-UHFFFAOYSA-N

CAS DataBase Reference

442632-72-6

 

Safety Information

Hazard Codes 

Xn

Risk Statements 

22

WGK Germany 

3

MSDS Information

 

CK-636 Usage And Synthesis

Description

CK-636 is an Arp2/3 complex inhibitor with IC50 of 4 μM, 24 μM and 32 μM for inhibition of actin polymerization induced by human, fission yeast and bovine Arp2/3 complex, respectively.

In vitro

CK-636 inhibits actin polymerization mediated by Arp2/3 complex in live cells, and reduces the formation of actin filament comet tails by Listeria in infected SKOV3 cells. CK-636 inhibits lamellipodia formation at the leading edges of migrating T cells, and causes reduced velocity. In addition, a substantial fraction of CK-636-treated T cells on zigzag patterns with an acute turning angle are trapped near the interfaces formed by the turning points of zigzag patterns.