Y320
| Price | $5 |
| Package | 5KG |
| Min. Order: | 1KG |
| Supply Ability: | 1ton |
| Update Time: | 2019-09-04 |
Product Details
| Product Name: Y320 | CAS No.: 288250-47-5 |
| EC-No.: 200-256-5 | Min. Order: 1KG |
| Purity: 99% | Supply Ability: 1ton |
| Release date: 2019/09/04 | |
| contact person: Flora |
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Y320 Basic information
Description In vitro In vivo
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Product Name:
Y320
Synonyms:
288250-47-5;Y320;1-(4-Chlorophenyl)-N-[3-cyano-4-[4-(4-morpholinyl)-1-piperidinyl]phenyl]-5-methyl-1H-pyrazole-4-carboxamide;1-(4-Chlorophenyl)-N-[3-cyano-4-[4-(4-morpholinyl)-1-piperidinyl]phenyl]-5-methyl-1H-pyrazole-4-carboxamide Y320;Y320 1-(4-Chlorophenyl)-N-[3-cyano-4-[4-(4-morpholinyl)-1-piperidinyl]phenyl]-5-methyl-1H-pyrazole-4-carboxamide;Y-320, >=98%;1-(4-Chlorophenyl)-N-(3-cyano-4-(4-morpholinopiperidin-1-yl)phenyl)-5-methyl-1H-pyrazole-4-car;1-(4-Chlorophenyl)-N-(3-cyano-4-(4-morpholinopiperidin-1-yl)phenyl)-5-methyl-1H-pyrazole-4-carboxami
CAS:
288250-47-5
MF:
C27H29ClN6O2
MW:
505.01116
EINECS:
Product Categories:
Inhibitors
Mol File:
288250-47-5.mol
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Y320 Chemical Properties
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Safety Information
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MSDS Information
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Y320 Usage And Synthesis
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Description
Y-320 is an orally active immunomodulator, and inhibits IL-17 production by CD4 T cells stimulated with IL-15 with IC50 of 20 to 60 nM.
In vitro
Y-320 also inhibits the production of IFN-γ and TNF-α by mouse CD4 T cells stimulated with IL-15, CXCL12, and anti-CD3 mAb.
In vivo
Y-320 (0.3-3 mg/kg p.o.) ameliorates collagen-induced arthritis (CIA) in Mice with a reduction of IL-17 mRNA in arthritic joints, and also shows therapeutic effects on CIA in cynomolgus monkeys. Moreover, Y-320 shows a synergistic effect in combination with anti-TNF-α mAb on chronic-progressing CIA in mice.
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Y320 Preparation Products And Raw materials
Company Profile Introduction
Established in 2014,Career Henan Chemical Co. is a manufacturerspecializing in the sale of fine chemicals.
Mainly deals in the sales of:
Pharmaceutical intermediates
OLED intermediates：
Pharmaceutical intermediates;
OLED intermediates;
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INQUIRY
楊俊青
sales@coreychem.com
sales@coreychem.com