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Postion:Product Catalog >Biochemical Engineering>Inhibitors>Autophagy>LRRK2 inhibitors> GNE 7915
	GNE 7915
  • 	GNE 7915
  • 	GNE 7915
  • 	GNE 7915

GNE 7915

Price $1
Package 1g
Min. Order: 1g
Supply Ability: 20kg
Update Time: 2019-12-24

Product Details

Product Name: GNE 7915 CAS No.: 1351761-44-8
Min. Order: 1g Purity: 99%
Supply Ability: 20kg Release date: 2019/12/24

Mary

 

Product Name:
GNE 7915
Synonyms:
GNE 7915;[4-[[4-(Ethylamino)-5-(trifluoromethyl)-2-pyrimidinyl]amino]-2-fluoro-5-methoxyphenyl]-4-morpholinylmethanone;GNE-7915, >=98%;(4-((4-(Ethylamino)-5-(trifluoromethyl)pyrimidin-2-yl)amino)-2-fluoro-5-methoxyphenyl)(morphol;(4-((4-(ethylamino)-5-(trifluoromethyl)pyrimidin-2-yl)amino)-2-fluoro-5-methoxyphenyl)(morpholino)methanone
CAS:
1351761-44-8
MF:
C19H21F4N5O3
MW:
443.3953528
EINECS:
 
Product Categories:
api;Inhibitors
Mol File:
1351761-44-8.mol
Article illustration
 
GNE 7915 Chemical Properties
Boiling point 
629.9±65.0 °C(Predicted)
density 
1.404±0.06 g/cm3(Predicted)
pka
2.80±0.10(Predicted)
 
Safety Information
MSDS Information
 
 
GNE 7915 Usage And Synthesis
Uses
Leucine-rich repeat kinase 2 (LRRK2) is an enzyme that interacts with parkin, a ligase that is part of the ubiquitin-proteasome system that mediates the targeting of proteins for degradation. Loss of function of the parkin protein leads to dopaminergic cell death. The development of Parkinson's disease has been strongly associated with mutations in the LRRK2 gene that lead to increased kinase activity. GNE-7915 is a selective, brain-penetrable LRRK2 inhibitor (Kis = 2 and 18.7 nM in biochemical and cell-based assays, respectively). It inhibits LRRK2 Ser1292 autophosphorylation in BAC transgenic mice expressing human LRRK2 protein with the G2019S Parkinson’s disease mutation with an IC50 value of 20 nM in vivo.[Cayman Chemical]
 
GNE 7915 Preparation Products And Raw materials

 
 

Company Profile Introduction

Established in 2014,Career Henan Chemical Co. is a manufacturerspecializing in the sale of fine chemicals. Mainly deals in the sales of: Pharmaceutical intermediates OLED intermediates: Pharmaceutical intermediates; OLED intermediates;

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