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Postion:Product Catalog >API>Antibiotics>Other antibiotic Drugs>LEPTOMYCIN B FROM STREPTOMYCES SP
LEPTOMYCIN B FROM STREPTOMYCES SP
  • LEPTOMYCIN B FROM STREPTOMYCES SP
  • LEPTOMYCIN B FROM STREPTOMYCES SP
  • LEPTOMYCIN B FROM STREPTOMYCES SP
  • LEPTOMYCIN B FROM STREPTOMYCES SP
  • LEPTOMYCIN B FROM STREPTOMYCES SP

LEPTOMYCIN B FROM STREPTOMYCES SP

Price $1
Package 1g
Min. Order: 1g
Update Time: 2019-12-26

Product Details

Product Name: LEPTOMYCIN B FROM STREPTOMYCES SP CAS No.: 87081-35-4
EC-No.: 617-954-4 Min. Order: 1g
Purity: ≥98% Supply Ability: g/kg/Ton
Release date: 2019/12/26
Delivery Time: Prompt Packaging: Bottle/Durm/Bag
Transportation: By air/Bay Sea/Express

Heidi 0703

Email:heidi@coreychem.com

LEPTOMYCIN B FROM STREPTOMYCES SP Basic information
Product Name:
LEPTOMYCIN B FROM STREPTOMYCES SP
Synonyms:
InSolution Leptomycin B, Streptomyces sp. - CAS 87081-35-4 - Calbiochem;LEPTOMYCIN B FROM STREPTOMYCES SP;Leptomycin B (CI 940;2,10,12,16,18-nonadecapentanoicacid,19-(3,6-dihydro-3-methyl-6-oxo-2h-pyran-2;7,9,11,15-hexamethyl-8-oxo--yl)-17-ethyl-6-hydroxy-5;antibioticci940;antibioticcl1957a;CI-940, Elactocin, PD 114720, ATS 1287B, Mantuamycin, 19-(3,6-dihydro-3-methyl-6-oxo-2H-pyran-2-yl)-17-ethyl-6-hydroxy-3,5,7,9,11,15-hexamethyl-8-oxo-2,10,12,16,18-Nonadecapentaenoic acid
CAS:
87081-35-4
MF:
C33H48O6
MW:
540.736
EINECS:
617-954-4
Product Categories:
Antifungal;antibiotic
Mol File:
87081-35-4.mol
Article illustration
 
LEPTOMYCIN B FROM STREPTOMYCES SP Chemical Properties
Melting point 
41-44°, with prior softening (Hokanson)
alpha 
D -24.5° (c = 0.70 in MeOH); D23 -157 ° (c = 0.7% in chloroform)
Fp 
11°(52°F)
storage temp. 
−20°C
form 
Liquid
 
Safety Information
Hazard Codes 
F,T
Risk Statements 
23/25-36/38-39/23/24/25-23/24/25-11
Safety Statements 
7-16-24-33-45-36/37
RIDADR 
UN 1230 3/PG 2
WGK Germany 
3
HazardClass 
3
HS Code 
29419090
MSDS Information
 
 
LEPTOMYCIN B FROM STREPTOMYCES SP Usage And Synthesis
Uses
Leptomycin B is the dominant and most studied member of the leptomycin class, isolated from selected Streptomyces strains. Leptomycin B is a nanomolar active and specific nuclear export inhibitor. Its target is CRM1/exportin1, a protein in the nuclear export sequence (NES). Proteins affected include c-Abl, cyclin B1, HIV-1 Rev, IκB, MPF, MAP/ERK, MDM2/p53, NF-κB/IκB7 and PKA. Leptomycin B inhibits export of many RNAs, e.g. COX-2 and c-FOS mRNA. Leptomycin B also shows antifungal and antibacterial and potent antitumour activities.
Uses
Leptomycin B is the dominant and most studied member of the leptomycin class, isolated from selected Streptomyces strains. Leptomycin B is a nanomolar active and specific nuclear export inhibitor. Its target is CRM1/exportin1, a protein in the nuclear export sequence (NES). Proteins affected include c-Abl, cyclin B1, HIV-1 Rev, IκB, MPF, MAP/ERK, MDM2/p53, NF-κB/IκB7 and PKA. Leptomycin B inhibits export of many RNAs, e.g. COX-2 and c-FOS mRNA. Leptomycin B also shows antifungal, antibacterial and potent antitumor activities.
Uses
Biological tool for studying nuclear localization and protein trafficking in eukaryotic cells.
Definition
ChEBI: A leptomycin having a (2E,10E,12E,16Z,18E)-double bond configuration as well as an ethyl substituent at position 17.
Biological Activity
Antifungal antibiotic that is an inhibitor of the nuclear export of proteins; acts by binding directly to and inhibiting CRM1/exportin-1. Inhibits the nuclear export of the HIV regulatory protein Rev and stabilizes p53. Antitumor in vitro and in vivo .

Company Profile Introduction

Established in 2014,Career Henan Chemical Co. is a manufacturerspecializing in the sale of fine chemicals. Mainly deals in the sales of: Pharmaceutical intermediates OLED intermediates: Pharmaceutical intermediates; OLED intermediates;

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