lactacystin
| Price | $1 |
| Package | 1g |
| Min. Order: | 1g |
| Supply Ability: | 1ton |
| Update Time: | 2020-01-13 |
Product Details
| Product Name: lactacystin | CAS No.: 133343-34-7 |
| EC-No.: 200-258-5 | Min. Order: 1g |
| Purity: 95-99% | Supply Ability: 1ton |
| Release date: 2020/01/13 | |
| contact: Mary@coreychem.com |
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Common Name
lactacystin
CAS Number
133343-34-7
Molecular Weight
376.425
Density
1.4±0.1 g/cm3
Boiling Point
714.9±60.0 °C at 760 mmHg
Molecular Formula
C15H24N2O7S
Melting Point
233-235ºC dec.
MSDS
ChineseUSA
Flash Point
386.1±32.9 °C
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Use of lactacystin
Lactacystin, an antibiotic Streptomyces spp. metabolite, is a potent and selective proteasome inhibitor with an IC50 of 4.8 μM for 20S proteasome. Lactacystin also inhibits the lysosomal enzyme cathepsin A[1]. Lactacystin inhibits cell growth and induces neurite outgrowth[2].
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Name
lactacystin
Synonym
More Synonyms
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Description
Lactacystin, an antibiotic Streptomyces spp. metabolite, is a potent and selective proteasome inhibitor with an IC50 of 4.8 μM for 20S proteasome. Lactacystin also inhibits the lysosomal enzyme cathepsin A[1]. Lactacystin inhibits cell growth and induces neurite outgrowth[2].
Related Catalog
Signaling Pathways >> Metabolic Enzyme/Protease >> Proteasome
Research Areas >> Neurological Disease
Target
IC50: 4.8 μM (proteasome)[1]
In Vivo
Lactacystin (microinjection; 2 µg) induces a Parkinson’s disease-like motor phenotype 5-7 days after injection in young and adult mice[2]. Animal Model: Male C57Bl/6RccHsd mice with 8-9 weeks (young) and 12-14 months (adult) old[2] Dosage: 2 µg Administration: Microinjection Result: Induced a Parkinson’s disease-like motor phenotype 5-7 days after injection in young and adult mice.
References
[1]. Csizmadia V, et al. Effect of proteasome inhibitors with different chemical structures on the ubiquitin-proteasomesystem in vitro. Vet Pathol. 2010 Mar;47(2):358-67.
[2]. Savolainen MH, et al. Nigral injection of a proteasomal inhibitor, lactacystin, induces widespread glial cell activationand shows various phenotypes of Parkinson's disease in young and adult mouse. Exp Brain Res. 2017 Jul;235(7):2189-2202.
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Density
1.4±0.1 g/cm3
Boiling Point
714.9±60.0 °C at 760 mmHg
Melting Point
233-235ºC dec.
Molecular Formula
C15H24N2O7S
Molecular Weight
376.425
Flash Point
386.1±32.9 °C
Exact Mass
376.130432
PSA
178.33000
LogP
-1.10
Vapour Pressure
0.0±5.2 mmHg at 25°C
Index of Refraction
1.560
Storage condition
−20°C
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Personal Protective Equipment
Eyeshields;G
Company Profile Introduction
Established in 2014,Career Henan Chemical Co. is a manufacturerspecializing in the sale of fine chemicals.
Mainly deals in the sales of:
Pharmaceutical intermediates
OLED intermediates：
Pharmaceutical intermediates;
OLED intermediates;
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