Product Details
| Product Name:
Lactacystin |
CAS No.:
133343-34-7 |
| Supply Ability:
10g |
Release date:
2026/05/11 |
Product Introduction
Bioactivity
| Name | Lactacystin |
| Description | Lactacystin is an orally active, irreversible, and cell-permeable proteasome inhibitor (IC50 = 4.8 μM) that also inhibits the lysosomal enzyme cathepsin A. It induces apoptosis and cell cycle arrest, possesses anticancer, antiviral, and antioxidant activities, can penetrate the blood-brain barrier, and is commonly used in the construction of Parkinson’s disease and dementia models. |
| In vitro | Methods: RA-differentiated SH-SY5Y cells were treated with lactacystin (2.5–10 μg/ml, 48 hours) to select the effective concentration for celastrol studies.
Results: Lactacystin at a concentration of 10 μg/ml (26.4 μM) reduced SH-SY5Y cell viability by 40-50%. [3] |
| In vivo | Methods: Lactacystin (5 μg/2 μl) was administered unilaterally into the left SNc of rats to study its effect on rat body weight.
Results: Lactacystin can reduce the body weight of rats. [3] |
| Storage | Store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 18 mg/mL (47.82 mM), Sonication and heating are recommended.
|
| Keywords | proteasome | Lactacystin |
| Inhibitors Related | Stavudine | Aceglutamide | Urea | Tamoxifen | Cysteamine hydrochloride | Metronidazole | Citric Acid Triammonium | Formamide | Dimethyl phthalate | Alginic acid | Sodium Molybdate | Sildenafil citrate |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
Recommended supplier
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Price |
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Suppliers |
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$1.00
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VIP7Y
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Career Henan Chemical Co
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2020-01-13 |
United States