Product Details
| Product Name:
Afegostat |
CAS No.:
169105-89-9 |
| Supply Ability:
10g |
Release date:
2026/05/19 |
Product Introduction
Bioactivity
| Name | Afegostat |
| Description | Afegostat is a pharmacological chaperone that specifically and reversibly binds acid-β-glucosidase (GCase) in the endoplasmic reticulum with high affinity. |
| In vivo | Afegostat enhances GCase activity in the brain, liver, and spleen. When administered orally at 100 mg/kg for four months to Thy1-aSyn mice, it not only improves motor and nonmotor functions but also eliminates the microglial inflammatory response in the substantia nigra. Additionally, it decreases α-synuclein immunoreactivity within nigral dopaminergic neurons and alters α-synuclein aggregation, reducing small aggregates while increasing large ones. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Shipping with blue ice/Shipping at ambient temperature. |
| Keywords | GCase | Afegostat |
| Inhibitors Related | Cedryl acetate | X-GAL | Hexylresorcinol | Conduritol B epoxide | Gcase activator 2 | Fucoidan | Miglitol | D-(-)-Quinic acid | (E)-3-(4-Methoxyphenyl)acrylic acid | Naringinase | Acarbose | 3-Butylidenephthalide |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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$987.00
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TargetMol Chemicals Inc.
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2026-04-21 |
United States