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Postion:Product Catalog >Biochemical Engineering>Biochemical Reagents>Agonist Inhibitors>AGN 194310
AGN 194310
  • AGN 194310

AGN 194310 NEW

Price $596 $1710 $2230
Package 5mg 25mg 50mg
Supply Ability: 10g
Update Time: 2026-05-11

Product Details

Product Name: AGN 194310 CAS No.: 229961-45-9
Supply Ability: 10g Release date: 2026/05/11

Product Introduction

Bioactivity

NameAGN 194310
DescriptionAGN 194310 (VTP-194310) is a pan-antagonist for retinoic acid receptors (RARs), with Kd values of 3 nM, 2 nM, and 5 nM for RARα, RARβ, and RARγ, respectively[1][2].
In vitroAGN194310 effectively inhibits colony formation in LNCaP, PC3, and DU-145 cells with IC50 values of 16 nM, 18 nM, and 34 nM, respectively[2]. At concentrations of 50 nM and 100 nM, both alone and combined with TTNPB, AGN194310 inhibits colony formation in these cell lines[2]. Additionally, treatment with AGN194310 (1 μM for 72 hours) results in 80% apoptosis in LNCaP cells[2].
In vivoAGN 194310 (0.5 mg/kg/day; oral gavage; every day; for 10 days; female C57Bl/6J mice) treatment significantly increases granulocyte numbers across hematopoietic compartments and the frequency of granulocyte-progenitor cells in bone marrow[3].
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.
Solubility Information10% DMSO+40% PEG300+5% Tween-80+45% Saline : 1.67 mg/mL (3.93 mM), Sonication is recommended.
DMSO : 50 mg/mL (117.77 mM), Sonication is recommended.
KeywordsVTP194310 | VTP 194310 | RetinoidReceptor | Retinoid Receptor | RARγ | RARβ | RARα | AGN-194310 | AGN194310 | AGN 194310
Inhibitors RelatedStavudine | Aceglutamide | Hemin | Tamoxifen | Cysteamine hydrochloride | Guanidine hydrochloride | Hydroxychloroquine | Enzalutamide | Paeonol | Naringin | Alginic acid | Sildenafil citrate

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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4YR United StatesUnited States
  • Since: 2011-01-07
  • Address: 36 Washington Street, Wellesley Hill, USA
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