AGN 194310 NEW
| Price | $596 | $1710 | $2230 |
| Package | 5mg | 25mg | 50mg |
| Supply Ability: | 10g |
| Update Time: | 2025-08-22 |
Product Details
| Product Name: AGN 194310 | CAS No.: 229961-45-9 |
| Supply Ability: 10g | Release date: 2025/08/22 |
Product Introduction
Bioactivity
| Name | AGN 194310 |
| Description | AGN 194310 (VTP-194310) is a pan-antagonist for retinoic acid receptors (RARs), with Kd values of 3 nM, 2 nM, and 5 nM for RARα, RARβ, and RARγ, respectively[1][2]. |
| In vitro | AGN194310 effectively inhibits colony formation in LNCaP, PC3, and DU-145 cells with IC50 values of 16 nM, 18 nM, and 34 nM, respectively[2]. At concentrations of 50 nM and 100 nM, both alone and combined with TTNPB, AGN194310 inhibits colony formation in these cell lines[2]. Additionally, treatment with AGN194310 (1 μM for 72 hours) results in 80% apoptosis in LNCaP cells[2]. |
| In vivo | AGN 194310 (0.5 mg/kg/day; oral gavage; every day; for 10 days; female C57Bl/6J mice) treatment significantly increases granulocyte numbers across hematopoietic compartments and the frequency of granulocyte-progenitor cells in bone marrow[3]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 50 mg/mL (117.77 mM), Sonication is recommended. |
| Keywords | VTP194310 | VTP 194310 | RetinoidReceptor | Retinoid Receptor | RARγ | RARβ | RARα | AGN-194310 | AGN194310 | AGN 194310 |
| Inhibitors Related | Isotretinoin | Oxybenzone | Adapalene | MSU-42011 | Retinoic acid | Tazarotene | Etodolac | ER 50891 | Acitretin | Tamibarotene | Bexarotene | TTNPB |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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