Alantolactone NEW
| Price | $50 | $65 | $144 |
| Package | 5mg | 10mg | 25mg |
| Supply Ability: | 10g |
| Update Time: | 2026-06-02 |
Product Details
| Product Name: Alantolactone | CAS No.: 546-43-0 |
| Purity: 99.91% | Supply Ability: 10g |
| Release date: 2026/06/02 |
Product Introduction
Bioactivity
| Name | Alantolactone |
| Description | Alantolactone is a selective inhibitor of STAT3 that induces cancer-associated apoptosis and has antitumor activity. |
| Cell Research | Cell viability was evaluated using MTT assay. The cells were seeded into 96-well plates and maintained at 37 °C for 24 h. The cells were treated with alantolactone for 24 h. The MTT solution (0.5 mg/mL) was added to each well, and the cells were incubated for another 3 h. The MTT formazan crystals were dissolved in DMSO. The results were obtained by measuring the absorbance at a wavelength of 540 nm using a microplate reader.(Only for Reference) |
| In vitro | METHODS: The inhibitory effects of Alanolactone (5, 10, 15μM) on the growth of MDA-MB-231, MCF-10A and MCF-7 cells were compared. RESULTS Alanolactone significantly inhibited cell proliferation of MDA-MB-231 cells compared with MCF-10A and MCF-7 cells. [1] METHODS: To investigate the effect of Alantolactone (5, 10, 15 μM) on the expression levels of STAT3-related proteins in MDA-MB-231 cells, Western blot analysis of p-STAT3, STAT3, p-JAK1, JAK1, p-JAK2, JAK2, p-Src, Src, p-ERK, and ERK was performed on MDA-MB-231 cell lysates. RESULTS Alantolactone selectively inhibited STAT3 phosphorylation, thereby suppressing the secondary signaling events of STAT3 inhibition and inhibiting MDA-MB-231 cell proliferation. [1] METHODS: U87, U373, and LN229 glioma cell lines were treated with alantolactone (10-60 μM) for 12 h, and cell viability was measured by MTT assay. RESULTS Alantolactone treatment increased the growth inhibition of U87, U373, and LN229 cells in a dose-dependent manner, with IC50 values ??of alantolactone for U87, U373, and LN229 cells being 33, 35, and 36 μM, respectively. [2] |
| In vivo | METHODS: To confirm the antitumor effect of Alanolactone in vivo, a xenograft experiment was performed on MDA-MB-231 cells. The cells were injected into athymic nude mice and treated with alanolactone (2.5 mg/kg, intraperitoneal injection, 14 days). RESULTS The average tumor volume of mice treated with alanolactone was approximately 2.17 times lower than that of control mice. Alantolactone administration did not affect the overall body weight and had no obvious toxicity to mice. [1] |
| Storage | Store at low temperature,Keep away from direct sunlight Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 250 mg/mL (1076.1 mM), Sonication is recommended. Ethanol : 46 mg/mL (198 mM), Sonication is recommended. 10% DMSO+90% Saline : 10 mg/mL (43.04 mM), Solution. 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 2 mg/mL (8.61 mM), Sonication is recommended. |
| Keywords | Transforming growth factor beta | TGF-β/Smad | TGFβ | TGF-beta/Smad | TGFbeta/Smad | TGF-beta | TGFbeta | TGF-b/Smad | TGFb | STAT | Smad | Inhibitor | inhibit | Apoptosis | Alantolactone |
| Inhibitors Related | Stavudine | Aceglutamide | Urea | Tamoxifen | Cysteamine hydrochloride | Metronidazole | Citric Acid Triammonium | Formamide | Dimethyl phthalate | Alginic acid | Sodium Molybdate | Sildenafil citrate |
| Related Compound Libraries | Bioactive Compound Library | Selected Plant-Sourced Compound Library | Anti-Inflammatory Traditional Chinese Medicine Compound Library | Natural Product Library | Inhibitor Library | Natural Product Library for HTS | Immunology/Inflammation Compound Library | Anti-Aging Compound Library | Anti-virus Traditional Chinese Medicine Monomer Library | Ancient Chinese Classical Formulas Compound Library | Anti-Cancer Active Compound Library | TGF-beta/Smad Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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