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Postion:Product Catalog >AM-8735
AM-8735
  • AM-8735

AM-8735 NEW

Price $1820 $2380 $3100
Package 25mg 50mg 100mg
Supply Ability: 10g
Update Time: 2026-04-20

Product Details

Product Name: AM-8735 CAS No.: 1429386-01-5
Supply Ability: 10g Release date: 2026/04/20

Product Introduction

Bioactivity

NameAM-8735
DescriptionAM-8735 is an inhibitor of MDM2 ( IC50: 25 nM).
In vitroAM-8735 exhibits a dose-dependent increase of p21 mRNA, a direct transcriptional readout of p53 activity, in HCT116 p53wt cells (IC50=160 nM)[1]. AM-8735 displays substantial growth inhibition of wild-type p53 cells (IC50=63 nM) and no growth inhibition of p53-deficient cells (IC50>25 μM).
In vivoAM-8735 exhibits potent antitumor properties in the SJSA-1 osteosarcoma xenograft model, achieving an effective dose (ED50) of 41 mg/kg[1]. Additionally, AM-8735 significantly induces p21 mRNA expression in a time- and concentration-dependent manner within SJSA-1 osteosarcoma tumors, as demonstrated through in vivo pharmacodynamic assays.
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.
KeywordsMDM2 | AM-8735 | AM8735 | AM 8735
Inhibitors Related10-Hydroxydecanoic Acid | Flubendazole | Diuron | Gallium maltolate | Yucasin | D-(-)-3-Phosphoglyceric acid disodium | EN219 | Thiabendazole | Triglycidyl isocyanurate | Indole-3-carbinol | Methyl methanesulfonate | (E/Z)-10-Hydroxy-2-decenoic acid

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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  • Since: 2011-01-07
  • Address: 36 Washington Street, Wellesley Hill, USA
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