Product Details
| Product Name:
AM-6538 |
CAS No.:
1245626-00-9 |
| Supply Ability:
10g |
Release date:
2026/04/22 |
Product Introduction
Bioactivity
| Name | AM-6538 |
| Description | AM6538, a long-acting, high-affinity, and pseudo-irreversible cannabinoid antagonist structurally analogous to rimonabant, is a valuable tool for assessing the apparent efficacy of cannabinoid partial and full agonists. It also holds potential for future investigations requiring temporary reductions in cannabinoid receptor availability[1]. |
| In vitro | AM6538 acts as a cannabinoid antagonist, targeting CB1 receptors within HEK-293 cells, exhibiting wash-resistant binding properties[1]. |
| In vivo | AM6538 (1~10 mg/kg) effectively antagonizes the antinociceptive effects of cannabinoid agonists in mice[1], with 10 mg/kg indicating partial recovery of AM4054 effects. It decreases tau values for all cannabinoid agonists dose-dependently, reducing receptor availability and exerting lasting antagonism, significantly affecting tetrahydrocannabinol dose-effect function up to 7 days post-treatment[1]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Shipping with blue ice/Shipping at ambient temperature. |
| Keywords | AM-6538 | AM6538 | AM 6538 |
| Inhibitors Related | RTICBM-189 | β-Caryophyllene | CB2 modulator 1 | Pregnenolone | CB1 inverse agonist 1 | Pregnenolone acetate | CB1 antagonist 2 | CB2 receptor agonist 2 | AM-1235 | 2,3-Butanediol | Drinabant | AM281 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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