Antitumor agent-101 NEW
| Price | $1520 | $1980 | $2500 |
| Package | 25mg | 50mg | 100mg |
| Supply Ability: | 10g |
| Update Time: | 2026-04-20 |
Product Details
| Product Name: Antitumor agent-101 | CAS No.: 2848632-52-8 |
| Supply Ability: 10g | Release date: 2026/04/20 |
Product Introduction
Bioactivity
| Name | Antitumor agent-101 |
| Description | Antitumor agent-101 is a selective, covalent inhibitor targeting lysine methyltransferases G9a/GLP, demonstrating IC50 values of 8.5 nM for G9a and 5.5 nM for GLP. It exhibits antitumor efficacy in the PANC-1 xenograft model [1]. |
| In vitro | Antitumor agent-101 (Compound 27) (0-5 μM; 48 hours) inhibits proliferation and colony formation in PANC-1 and MDA-MB-231 cells [1]. Furthermore, Antitumor agent-101 (0-10 μM; 0-96 hours) effectively reduces H3K9me2 levels in these cells in a concentration- and time-dependent manner. |
| In vivo | Antitumor agent-101 (Compound 27), administered at 2 mg/kg via intraperitoneal injection five times per week, inhibits the growth of PANC-1 xenograft tumors by suppressing the methyltransferase activity of G9a/GLP [1]. Additionally, this compound demonstrates a peak plasma concentration (Cmax) of 316 ng/mL and a mean residence time (MRT) of 0.61 hours [1]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| Keywords | HistoneMethyltransferase | Histone Methyltransferase |
| Inhibitors Related | MAK-683 hydrochloride | Exendin-4 | SNDX-5613 | Tazemetostat | Semaglutide | Piribedil | XY1 | NNC 92-1687 | EPZ015666 | iso-Azalansta | MRTX-1719 | Orforglipron |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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