Antitumor agent-86 NEW
| Price | Get Latest Price | |
| Package | 5mg | 50mg |
| Supply Ability: | 10g |
| Update Time: | 2026-04-20 |
Product Details
| Product Name: Antitumor agent-86 | CAS No.: 2907704-65-6 |
| Supply Ability: 10g | Release date: 2026/04/20 |
Product Introduction
Bioactivity
| Name | Antitumor agent-86 |
| Description | Antitumor agent-86 (compound 5a) demonstrates efficacy against MCF-7 breast cancer cells with an inhibitory concentration (IC 50) of 2.62 μM, promoting apoptosis and cell cycle arrest by disrupting the RAS/PI3K/Akt/JNK signaling pathways [1]. |
| In vitro | Antitumor agent-86, administered at concentrations ranging from 0-200 μM for 48 hours, dose-dependently suppresses proliferation in MCF-7, MDA-MB-231, Caco-2, and PANC-1 cancer cell lines, with respective IC50 values of 2.617, 6.778, 14.8, and 23.58 μM [1]. At a concentration of 2.62 μM over 48 hours, it induces apoptosis, cell cycle arrest, reduces levels of p-RAS protein in MCF-7 cells, decreases mRNA transcription levels of PI3K and Akt, and lowers the expression of p-JNK protein [1]. Furthermore, Antitumor agent-86 upregulates the expression of the p21 gene at the same concentration and duration [1]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| Inhibitors Related | Aceglutamide | Musk ketone | Stearamide | Bisphenol A | Myricetin | Creatine monohydrate | Hyaluronic acid | Ethyl linoleate | Artemisinin | Methyl eugenol | Chloramphenicol | 2,3-Butanediol |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, Massachusetts, USA
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