AR453588 NEW
| Price | $1650 | $2150 | $3400 |
| Package | 25mg | 50mg | 100mg |
| Supply Ability: | 10g |
| Update Time: | 2025-08-22 |
Product Details
| Product Name: AR453588 | CAS No.: 1065609-00-8 |
| Supply Ability: 10g | Release date: 2025/08/22 |
Product Introduction
Bioactivity
| Name | AR453588 |
| Description | AR453588 is an orally bioavailable anti-diabetic glucokinase activator (EC50: 42 nM) with anti-hyperglycemic activity. |
| In vivo | AR453588 (3-30 mg/kg; p.o) reduces post-prandial glucose in normal C57BL/6J mice and exhibits anti-hyperglycemic activity in a dose-ranging 14-day ob/ob mouse study (3-30 mg/kg; p.o.; once-daily for 14 days). Following AR453588 (10 mg/kg; p.o.) administration, Tmax, AUCinf, Vss, Cmax, and F are 1.0 mL/min/kg, 4.65 h μg/mL, 1.67 μg/mL, and 60.3%, respectively. With AR453588 (1 mg/kg; i.v.) administration, the CL, AUCinf, Vss, and t1/2 are 21.6 mL/min/kg, 0.77 h μg/mL, 0.746 L/kg, and 1.28 hours, respectively. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Keywords | AR 453588 | AR453588 | AR-453588 |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, Massachusetts, USA
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