Artesunate NEW
| Price | $33 | $33 | $47 | $47 | $77 | $77 |
| Package | 25mg | 25mg | 50mg | 50mg | 100mg | 100mg |
| Supply Ability: | 10g |
| Update Time: | 2026-05-15 |
Product Details
| Product Name: Artesunate | CAS No.: 88495-63-0 |
| Purity: 99.90% | Supply Ability: 10g |
| Release date: 2026/05/15 |
Product Introduction
Bioactivity
| Name | Artesunate |
| Description | Artesunate (WR-256283) is a semisynthetic derivative of artemisinin and an inhibitor of STAT-3/EXP1. Water-soluble yet relatively unstable in neutral or acidic aqueous solutions, Artesunate is primarily employed for the treatment of malaria. |
| Cell Research | Growth inhibition assay: The SKM-1 cells (1×105/mL) are firstly seeded in 96-well plates. Artesunate is diluted in 0.1% dimethyl sulfoxide (DMSO) producing 0, 12.5, 25, 50µg/mL concentrations and added to the SKM-1 cells with 100 µl per well. A negative control is treated with 0.1% DMSO. At 0, 24, 48, and 72 hours, same amount of MTT solution is added into each well and cultured for extra 4 hours. MTT treated cells are fixed with 150 µL DMSO for 30 min at room temperature and then determined with Evolution 201 and 220 UV-Vis spectrophotometer system at 540 nm. (Only for Reference) |
| In vitro | Methods: SKM-1 cells were treated with 0–50 μg/mL Artesunate for 48 h. Methylation-specific PCR was used to detect CDH1 methylation status, while Western blot and laser confocal microscopy were employed to detect E-cadherin expression and localization. Results: Artesunate treatment induced CDH1 demethylation, restored E-cadherin expression, and promoted its aggregation to the cell membrane.[1] Methods: Human glioma SHG44 cells were treated with 0–50 mg/L Artesunate for 24–48 h. Cell proliferation was detected by MTT assay, apoptosis by flow cytometry, migration and invasion by Transwell assay, biomechanical properties by atomic force microscopy, and claudin-1 expression by RT-PCR and Western blot. Results: Treatment with 30 mg/L Artesunate for 48 h significantly inhibited cell proliferation, migration, and invasion, induced apoptosis rate to 23.7%, while increasing cell adhesion force and membrane roughness, decreasing elasticity, and upregulating claudin-1 expression.[2] |
| In vivo | Methods: HeLa cell xenograft nude mice were randomly divided into groups. The Artesunate group received daily intraperitoneal injection of 100 mg/kg (diluted in sterile PBS) for 7 consecutive days, while the irradiation group received 10 Gy irradiation on day 7. Results: Combined treatment reduced tumor volume by 72.34%, significantly higher than 41.22% with irradiation alone, confirming the in vivo radiosensitizing effect of ART.[3] |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | Ethanol : 9 mg/mL (23.41 mM), Sonication is recommended. H2O : < 1 mg/mL (insoluble or slightly soluble) 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 5 mg/mL (13.01 mM), Sonication is recommended. DMSO : 250 mg/mL (650.33 mM), Sonication is recommended. |
| Keywords | WR256283 | WR 256283 | VirusProtease | Virus Protease | STAT | Parasite | Inhibitor | inhibit | Ferroptosis | Artesunate |
| Inhibitors Related | Hemin | Phenytoin sodium | Acetylcysteine | Kojic acid | Hydroxychloroquine | Metronidazole | 2-Amino-2-methyl-1-propanol | Doxycycline | Fenpyroximate | L-Cystine | Thymidine | Sodium Molybdate |
| Related Compound Libraries | Anti-Tumor Natural Product Library | Terpene Natural Product Library | Bioactive Compound Library | Traditional Chinese Medicine Monomer Library | Selected Plant-Sourced Compound Library | Miao medicine Compound Library | Drug Repurposing Compound Library | Natural Product Library | Anti-Cancer Approved Drug Library | Anti-infective Natural Product Library | Bioactive Compounds Library Max | Anti-Cancer Drug Library |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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