Product Details
| Product Name:
ATN-161 |
CAS No.:
262438-43-7 |
| Supply Ability:
10g |
Release date:
2026/05/11 |
Product Introduction
Bioactivity
| Name | ATN-161 |
| Description | ATN-161 is an integrin α5β1 binding peptide and antagonist that inhibits VEGF-induced hCECs migration and angiogenesis. ATN-161 also suppresses spike protein interaction with integrin α5β1 and may be employed against SARS-CoV-2 infection. |
| In vitro | Compared to the control group and monotherapy, ATN-161 combined with 5-FU significantly inhibited tumor cell proliferation and markedly increased the number of apoptotic (TUNEL-positive) tumor cells. In comparison to the control group, ATN-161 reduced endothelial cell (EC) counts by 21% after 48 hours of incubation [1]. ATN-161 was able to inhibit VEGF-induced migration of Homo sapiens corneal endothelial cells (hCECs) and the formation of capillary-like tubular structures, but showed no inhibitory effect on cell proliferation. Starting from a concentration of 100 nM, ATN-161 reduced VEGF-induced cell migration in a dose-dependent manner[2]. |
| In vivo | In the α5β1-negative human colon cancer xenograft model (HT29), ATN-161 treatment significantly reduced tumor weight and vascular density [1]. Intravitreal injection of ATN-161 after laser photocoagulation effectively suppressed leakage and neovascularization of choroidal neovascularization (CNV), with efficacy comparable to that of AF564 [2]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 20 mg/mL (33.46 mM)
H2O : ≥ 8 mg/mL
|
| Keywords | Integrin α5β1 | ATN-161 | ATN161 | ATN 161 |
| Inhibitors Related | K34c hydrochloride | Cucurbitacin B | Tirofiban hydrochloride monohydrate | (R)-Leucic acid | Lifitegrast | Cyclo(-RGDfK) | ADH-503 | Elsibucol | CLT-28643 | Bestatin hydrochloride | Gantofiban | 2-hydroxy Flutamide |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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