ATN-161 NEW
| Price | $2120 | $2780 | $3700 |
| Package | 25mg | 50mg | 100mg |
| Supply Ability: | 10g |
| Update Time: | 2025-07-17 |
Product Details
| Product Name: ATN-161 | CAS No.: 262438-43-7 |
| Supply Ability: 10g | Release date: 2025/07/17 |
Product Introduction
Bioactivity
| Name | ATN-161 |
| Description | ATN-161, a novel integrin α5β1 antagonist, inhibits angiogenesis and the growth of liver metastases in a murine model. |
| In vitro | The combination of ATN-161 and 5-FU markedly diminishes tumor cell growth and significantly enhances the percentage of apoptotic (TUNEL-positive) tumor cells better than either control or single-agent treatments. Contrarily, treatments involving only a single agent do not elevate levels of TUNEL-positive tumor cells. Moreover, ATN-161 alone achieves a notable reduction in endothelial cell (EC) count by 21% after 48 hours, underscoring its potency against the control [1]. Furthermore, while ATN-161 effectively obstructs VEGF-induced migration and capillary tube formation in human coronary endothelial cells (hCECs), it does not affect their proliferation. Notably, ATN-161 progressively decreases VEGF-stimulated cell migration in a dose-dependent fashion, starting at 100 nM, thereby demonstrating significant efficacy (P<0.001 versus VEGF group) [2]. |
| In vivo | Preliminary experiments on α5β1-negative human colon cancer xenografts (HT29) demonstrate that ATN-161 treatment significantly diminishes both tumor weight and vessel density [1]. Furthermore, administering ATN-161 following laser photocoagulation effectively suppresses choroidal neovascularization (CNV) leakage and neovascularization, achieving results comparable to those with AF564 [2]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Keywords | Integrin α5β1 | ATN-161 | ATN161 | ATN 161 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, USA
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