一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

Welcome to chemicalbook!
+1 (818) 612-2111
RFQ
Try our best to find the right business for you.
Do not miss inquiry messages Please log in to view all inquiry messages.

Welcome back!

RFQ
skype
MY Account
Top
Postion:Product Catalog >AV-412
AV-412
  • AV-412

AV-412 NEW

Price $37 $53 $87
Package 1mg 2mg 5mg
Supply Ability: 10g
Update Time: 2026-05-11

Product Details

Product Name: AV-412 CAS No.: 451493-31-5
Purity: 99.92% Supply Ability: 10g
Release date: 2026/05/11

Product Introduction

Bioactivity

NameAV-412
DescriptionAV-412 (MP412) is an EGFR inhibitor for EGFR, EGFR T790M, EGFR L858R, EGFR L858R/T790M, and ErbB2, with IC50 values of 0.75, 0.79, 0.5, 2.3, and 19 nM, respectively.
In vitroIn cells, MP-412 inhibited autophosphorylation of EGFR and ErbB2 with IC(50) of 43 and 282 nM, respectively. It also inhibited epidermal growth factor (EGF)-dependent cell proliferation with an IC(50) of 100 nM. Moreover, MP-412 abrogated EGFR signaling in the gefitinib-resistant H1975 cell line, which harbors a double mutation of L858R and T790M in EGFR.
In vivoIn animal studies using cancer xenograft models, MP-412 (30 mg/kg) demonstrated complete inhibition of tumor growth in A431 and BT-474 cell lines, which overexpress EGFR and ErbB2, respectively. MP-412 suppressed EGFR and ErbB2 autophosphorylation at doses corresponding to its antitumor efficacy. Various dosing schedules showed significant effects with daily and every-other-day schedules, but not with a once-weekly schedule, suggesting frequent dosing is preferable. Additionally, MP-412 exhibited significant antitumor effects on the ErbB2-overexpressing KPL-4 breast cancer cell line, which is resistant to gefitinib. These studies indicate MP-412's potential as a therapeutic for cancers expressing EGFR and ErbB2, especially those resistant to first-generation small-molecule inhibitors.
StorageStore at low temperature Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.
Solubility InformationDMSO : 135 mg/mL (158.56 mM), Sonication is recommended.
10% DMSO+40% PEG300+5% Tween 80+45% Saline : 2 mg/mL (2.35 mM), Sonication is recommended.
KeywordsMP-412 | MP 412 | Inhibitor | inhibit | HER1 | ErbB2 | ErbB-1 | Epidermal growth factor receptor | EGFRT790M | EGFRL858R/T790M | EGFRL858R | EGFR (T790M) | EGFR (L858R/T790M) | EGFR (L858R) | EGFR | AV-412 | AV412 | AV 412
Inhibitors Related(S)-Afatinib | Osimertinib | Lidocaine Hydrochloride hydrate | Lapatinib | Erlotinib hydrochloride | Erlotinib | Neratinib | Afatinib | Chalcone | Brigatinib | Genistein | Gefitinib
Related Compound LibrariesFailed Clinical Trials Compound Library | Bioactive Compound Library | Membrane Protein-targeted Compound Library | Kinase Inhibitor Library | Tyrosine Kinase Inhibitor Library | Anti-Cancer Clinical Compound Library | Drug Repurposing Compound Library | Inhibitor Library | Immunology/Inflammation Compound Library | Bioactive Compounds Library Max | Anti-Cancer Drug Library | Anti-Cancer Active Compound Library

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

You may like

Recommended supplier

Product name Price   Suppliers Update time
$66.00
VIP4Y
TargetMol Chemicals Inc.
2026-04-22
$1980.00
VIP2Y
TargetMol Chemicals Inc.
2026-04-21
VIP7Y
Shaanxi Dideu Medichem Co. Ltd
2025-12-24
$37.00
VIP4Y
TargetMol Chemicals Inc.
2026-05-11
$1.00
VIP7Y
Career Henan Chemical Co
2020-01-02

TargetMol Chemicals Inc.

6YR United StatesUnited States
  • Since: 2011-01-07
  • Address: 36 Washington Street, Wellesley Hill, MA
INQUIRY
香港 | 九台市| 阿拉善左旗| 黑龙江省| 怀仁县| 无锡市| 鹤岗市| 合川市| 宁武县| 海淀区| 景德镇市| 淳安县| 镶黄旗| 七台河市| 奉化市| 新宁县| 宣恩县| 荣成市| 三门县| 左权县| 旺苍县| 开江县| 班戈县| 综艺| 大安市| 万宁市| 香格里拉县| 丹阳市| 临夏县| 宁晋县| 浏阳市| 安西县| 抚宁县| 马关县| 称多县| 余江县| 龙江县| 秀山| 玛沁县| 美姑县| 谷城县|