Product Details
| Product Name:
Bamirastine |
CAS No.:
215529-47-8 |
| Purity:
96.68% |
Supply Ability:
10g |
| Release date:
2026/04/21 |
Product Introduction
Bioactivity
| Name | Bamirastine |
| Description | Bamirastine inhibits ligand binding to recombinant human histamine H1 receptor (rhH1R) with an IC50 of 17.3 nM and possesses an inhibitory effect on allergic skin inflammation. |
| In vitro | In a concentration-dependent manner, Bamirastine (TAK-427) reduces the specific binding of [3H] pyrilamine to recombinant human H1 receptors (rhH1R) with an IC50 value of 17.3 nM. The calculated Ki value for this interaction is 7.35 nM. Notably, the affinity of Bamirastine is determined to be as high as that of azelastine, 2 times lower than that of Epinastine, 8 times lower than that of ketotifen, and 3 times higher than that of Terfenadine[1]. |
| In vivo | Bamirastine (TAK-427) exhibits inhibition of histamine-induced skin reactions in guinea pigs and mice, with ID50 values of 0.884 and 0.450 mg/kg, p.o., respectively. Notably, significant inhibition persists 24 hours after dosing in guinea pigs even at a dose of 10 mg/kg. However, even at a high dose of 300 mg/kg, Bamirastine does not affect pentobarbital-induced sleeping time in mice.
Furthermore, Bamirastine significantly inhibits passive cutaneous anaphylaxis (PCA) in both mice and guinea pigs. Additionally, it inhibits antigen-induced immediate skin reactions (ISRs) in guinea pigs[1]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Shipping with blue ice/Shipping at ambient temperature. |
| Keywords | TAK427 | TAK 427 | rhH1R | HistamineReceptor | Histamine Receptor | H1 receptor | Bamirastine |
| Inhibitors Related | Undecane | Betahistine mesylate | Histamine dihydrochloride | Meclizine dihydrochloride | Lidocaine | Famotidine | Sodium butanoate | Nizatidine | Alginic acid | Mianserin hydrochloride | Trazodone hydrochloride | Doxepin hydrochloride |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
Recommended supplier
| Product name |
Price |
|
Suppliers |
Update time |
|
|
$700.00
|
VIP2Y
|
TargetMol Chemicals Inc.
|
2025-08-22 |
United States