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Postion:Product Catalog >MK-8353
MK-8353
  • MK-8353

MK-8353 NEW

Price $74 $158 $286
Package 1mg 5mg 10mg
Supply Ability: 10g
Update Time: 2026-06-02

Product Details

Product Name: MK-8353 CAS No.: 1184173-73-6
Purity: 96.15% Supply Ability: 10g
Release date: 2026/06/02

Product Introduction

Bioactivity

NameMK-8353
DescriptionMK-8353 (SCH900353) is a potent, selective, and orally available inhibitor of ERK1/2 with IC50 values of 23.0 nM and 8.8 nM, respectively.
In vitroMK-8353 is a potent, selective, and orally available ERK1/2 inhibitor with IC50 values of 23.0 nM and 8.8 nM, respectively; it exhibits antitumor activity.
In vivoMK-8353 causes at least 50% tumor growth inhibition or regression in 83% of the animal models bearing different tumor cells[1].
StorageStore at low temperature Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.
Solubility Information10% DMSO+40% PEG300+5% Tween 80+45% Saline : 10 mg/mL (14.45 mM), Solution.
10% DMSO+90% Saline : < 10 mg/mL (14.45 mM), Lower concentrations may be soluble, but exact solubility limit is unknown.
DMSO : 150 mg/mL (216.81 mM), Sonication is recommended.
KeywordsSCH-900353 | SCH 900353 | MK-8353 | MK8353 | MK 8353 | Inhibitor | inhibit | Extracellular signal regulated kinases | ERK2 | ERK1 | ERK
Inhibitors RelatedTBHQ | Urea | Gum arabic | L-Cysteine | β-Glycerophosphate disodium salt pentahydrate | 4-Methylbenzylidene camphor | Lactose | Astragaloside IV | Tauroursodeoxycholate | Propoxur | Gluconate Calcium | β-Glycerophosphate disodium salt hydrate
Related Compound LibrariesFailed Clinical Trials Compound Library | Pain-Related Compound Library | Bioactive Compound Library | Kinase Inhibitor Library | Anti-Cancer Clinical Compound Library | Drug Repurposing Compound Library | Inhibitor Library | Immunology/Inflammation Compound Library | Anti-Aging Compound Library | Bioactive Compounds Library Max | Anti-Cancer Drug Library | Anti-Cancer Active Compound Library

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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4YR United StatesUnited States
  • Since: 2011-01-07
  • Address: 36 Washington Street, Wellesley Hill, USA
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