BAY-298 NEW
| Price | $3018 |
| Package | 25mg |
| Supply Ability: | 10g |
| Update Time: | 2025-10-28 |
Product Details
| Product Name: BAY-298 | CAS No.: 2471978-97-7 |
| Supply Ability: 10g | Release date: 2025/10/28 |
Product Introduction
Bioactivity
| Name | BAY-298 |
| Description | BAY-298 is an orally active and selective luteinizing hormone receptor (LH-R) antagonist with IC50s of 96 nM, 23 nM, and 78 nM for hLH (human LH), rLH (rat LH), and cLH (cynomolgus monkey LH), respectively. It is the first nanomolar hLH-R antagonist that reduces sex hormone levels in vivo [1]. |
| In vivo | BAY-298 administered orally at dosages ranging from 4.5 to 72 mg/kg/day over a period of 8 days, leads to a dose-dependent reduction in serum estradiol levels in proestrus in intact female rats. Additionally, when administered to female and male Wistar rats either intravenously (iv) at a dosage of 0.5 mg/kg or orally (po) at 2 mg/kg, BAY-298 exhibits half-lives of 31 hours and 33 hours, respectively, for iv and po routes. The maximum serum concentrations (Cmax) achieved are 0.28 kg/L for iv and 0.066 kg/L for po administration. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Keywords | rLH | hLH | cLH | BAY-298 | BAY298 | BAY 298 |
| Inhibitors Related | (R)-Elagolix | Fluorogestone acetate | Relugolix | Opigolix | Goserelin acetate | Linzagolix choline | LGnRH-III, lamprey acetate(147859-97-0 free base) | Alarelin Acetate | Cetrorelix diacetate | Sufugolix | Lecirelin acetate(61012-19-9 free base) | AG 045572 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, USA
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