BMS-819881 NEW
| Price | $1520 | $1980 | $2500 |
| Package | 25mg | 50mg | 100mg |
| Supply Ability: | 10g |
| Update Time: | 2026-04-21 |
Product Details
| Product Name: BMS-819881 | CAS No.: 1197420-05-5 |
| Supply Ability: 10g | Release date: 2026/04/21 |
Product Introduction
Bioactivity
| Name | BMS-819881 |
| Description | BMS-819881, a melanin-concentrating hormone receptor 1 (MCHR1) antagonist, binds rat MCHR1 with a Ki of 7 nM, and is selective and potent for CYP3A4 activity with an EC50 of 13 μM. |
| In vitro | BMS-819881 (Compound 27) binds 99.8% to rat serum proteins with a rat MCHR1 Ki of 7 nM. In cytochrome P450 (CYP) assays, it shows EC50 values >40 μM for CYP1A2, CYP2C9, CYP2C19, and CYP2D6, but 13 μM for CYP3A4. Binding to serum proteins is species-dependent: 99.8% in rats, 99.6% in dogs, and 99.3% in monkeys. FLIPR-based assays indicate BMS-819881 is a potent and selective MCHR1 antagonist (Kb=32 nM) that blocks MCH-stimulated Ca2+ mobilization in MCHR1-overexpressing cells but not in MCHR2-expressing cells at 10 μM. No activity is observed at 10 μM against a panel of 20 GPCRs associated with feeding homeostasis [1]. |
| In vivo | BMS-819881 exhibits a moderate terminal elimination half-life, with values recorded at 5.7 hours for rats, 32±8 hours for dogs, and 14±3 hours for cynomolgus monkeys, all administered at a dosage of 1 mg/kg intravenously[1]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| Keywords | rat MCHR1 | CYP3A4 | BMS-819881 | BMS819881 | BMS 819881 |
| Inhibitors Related | Tebuconazole | Oxadiazon | Musk ketone | Naringin dihydrochalcone | Ipriflavone | Benzyl alcohol | Sudan IV | Naringin | Tauroursodeoxycholate | Dibenzothiophene | Clarithromycin | Memantine hydrochloride |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, USA
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