BMS-819881 NEW
| Price | $1520 | $1980 | $2500 |
| Package | 25mg | 50mg | 100mg |
| Supply Ability: | 10g |
| Update Time: | 2025-07-17 |
Product Details
| Product Name: BMS-819881 | CAS No.: 1197420-05-5 |
| Supply Ability: 10g | Release date: 2025/07/17 |
Product Introduction
Bioactivity
| Name | BMS-819881 |
| Description | BMS-819881, a melanin-concentrating hormone receptor 1 (MCHR1) antagonist, binds rat MCHR1 with a Ki of 7 nM, and is selective and potent for CYP3A4 activity with an EC50 of 13 μM. |
| In vitro | BMS-819881 (Compound 27) binds 99.8% to rat serum proteins with a rat MCHR1 Ki of 7 nM. In cytochrome P450 (CYP) assays, it shows EC50 values >40 μM for CYP1A2, CYP2C9, CYP2C19, and CYP2D6, but 13 μM for CYP3A4. Binding to serum proteins is species-dependent: 99.8% in rats, 99.6% in dogs, and 99.3% in monkeys. FLIPR-based assays indicate BMS-819881 is a potent and selective MCHR1 antagonist (Kb=32 nM) that blocks MCH-stimulated Ca2+ mobilization in MCHR1-overexpressing cells but not in MCHR2-expressing cells at 10 μM. No activity is observed at 10 μM against a panel of 20 GPCRs associated with feeding homeostasis [1]. |
| In vivo | BMS-819881 exhibits a moderate terminal elimination half-life, with values recorded at 5.7 hours for rats, 32±8 hours for dogs, and 14±3 hours for cynomolgus monkeys, all administered at a dosage of 1 mg/kg intravenously[1]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Keywords | rat MCHR1 | CYP3A4 | BMS-819881 | BMS819881 | BMS 819881 |
| Inhibitors Related | Tebuconazole | 1-Ethynylnaphthalene | Diflubenzuron | Apigenin | Gemfibrozil | Fenofibrate | 1-Aminobenzotriazole | Methoxsalen | Naringin | Naringenin | Tauroursodeoxycholate | Doxepin hydrochloride |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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- Address: 36 Washington Street, Wellesley Hill, Massachusetts, USA
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