Product Details
| Product Name:
Butaprost |
CAS No.:
69685-22-9 |
| Supply Ability:
10g |
Release date:
2026/05/11 |
Product Introduction
Bioactivity
| Name | Butaprost |
| Description | Butaprost is a selective agonist of the prostaglandin E receptor EP2 that exhibits an EC50 of 33 nM and a Ki of 2.4 μM toward the murine EP2 receptor, while showing markedly lower activity against murine EP1, EP3, and EP4 receptors. Butaprost effectively attenuates fibrotic responses by inhibiting the TGF-β/Smad2 signaling pathway, supporting its utility in fibrosis, inflammation, and prostaglandin receptor signaling research. |
| In vitro | In hEP2-HEK293/EBNA cells, the compound (1-100 nM) induces a dose- and time-dependent increase in Nur77 mRNA (approx. 5-fold). In Madin-Darby canine kidney (MDCK) cells, treatment with 50 μM Butaprost counteracts TGF-β signaling by reducing fibronectin (FN) expression, inhibiting Smad2 phosphorylation (p-Smad2), and suppressing EMT [1][2][3][5]. |
| In vivo | In male C57BL/6 mice subjected to unilateral ureteral obstruction (UUO) surgery, Butaprost treatment (1-4 mg/kg; i.p.; twice daily; 7 days) was evaluated for its effects on renal fibrosis. Administration of the compound resulted in a reduction in the gene and protein expression levels of α-smooth muscle actin (α-SMA), fibronectin, and collagen 1A1 (Col1A1). These results indicate that Butaprost is associated with the attenuation of fibrosis development in this obstructive kidney injury model [1]. |
| Storage | Store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Shipping with blue ice/Shipping at ambient temperature. |
| Keywords | TR 4979 | Butaprost | (R)-Butaprost |
| Inhibitors Related | Melamine | Tranilast | SB-431542 | Hydrochlorothiazide | Rutin | Pirfenidone | Rebamipide | A 83-01 | Lornoxicam | Cetrimonium bromide | Galunisertib | p-Hydroxycinnamic acid |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
Recommended supplier
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Anhui Ruihan Technology Co., Ltd
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2023-08-21 |
United States