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Postion:Product Catalog >CA-074 methyl ester
CA-074 methyl ester
  • CA-074 methyl ester

CA-074 methyl ester NEW

Price $72 $117 $179
Package 2mg 5mg 10mg
Supply Ability: 10g
Update Time: 2026-05-11

Product Details

Product Name: CA-074 methyl ester CAS No.: 147859-80-1
Purity: 99.49% Supply Ability: 10g
Release date: 2026/05/11

Product Introduction

Bioactivity

NameCA-074 methyl ester
DescriptionCA-074 methyl ester (Cathepsin B Inhibitor IV) is a selective inhibitor of Cathepsin B (IC50=36.3 nM). CA-074 methyl ester has neuroprotective, anti-inflammatory and anti-cancer effects.
Cell ResearchHL-60 cells are pre-treated for 24 h with 200 μM BSO followed by 60 min with 1 mM DEM. Thereafter, the cells(1×106/ml) are incubated with 100 μM CA-074 or CA-074Me, in the presence of 1% DMSO, 200 μM BSO and 1 mM DEM at 37°C. Control cultures are treated with 1% DMSO alone or with 100 μM Z-FA-DMK in the presence of 200 μM BSO and 1 mM DEM. Untreated HL-60 cells are incubated with 100 μM CA-074 or CA-074Me, in the presence of 1% DMSO at 37°C. Untreated control cultures are incubated with 1% DMSO alone or with 100 μM Z-FA-DMK. After 2 h incubation, cells are washed three times with PBS/1% glucose and lysed in 100 mM citrate, pH 5.0, 2% Chaps (106 cells/100 μl). Subsequently, the lysate is centrifuged and the clarified supernatant used to assay for proteolytic activity.(Only for Reference)
Kinase AssayAfter seven days of cell culture and osteoclast generation, the media is removed and washed three times with PBS. BMMs are fixed with a fixing solution supplied by the manufacturer. The cells are incubated at 37°C with a solution containing deionized water, Fast Garnet GBC, Napthol phosphate, Acetate, and Tartrate for 1 h. The staining solution is removed, washed with PBS (3×), and air-dried. TRAP positive cells with three or more nuclei across whole culture area are counted as multinucleated osteoclasts using light microscopy.
In vitroMETHODS: C57BL/6J BMM cells were treated with CA-074 methyl ester (50 μM) for 24, 48 and 72 hours, and the target protein expression was detected by Western Blot. RESULTS: CA-074 methyl ester inhibited RANKL-stimulated c-FOS upregulation and subsequent NFATc1 self-amplification. [1]
In vivoMETHODS: To study the neuroprotective effect of CA-074 methyl ester, CA-074 methyl ester (1 μg, 10 μg) was administered to the hippocampus induced by global cerebral I/R injury. RESULTS: CA-074 methyl ester prevented necroptosis in hippocampal CA1 neurons induced by global cerebral I/R injury. CA-074 methyl ester pretreatment strongly inhibited lysosomal membrane disruption and cathepsin-B leakage. CA-074 methyl ester inhibited the overexpression and nuclear translocation of RIP3 and the reduction of NAD+ levels after I/R injury. Pretreatment with CA-074 methyl ester enhanced the upregulation of Hsp70. [2] METHODS: To study the effect of CA-074 methyl ester on osteoclastogenesis, CA-074 methyl ester (10, 30 mg/kg) was injected into the skull of mice. RESULTS: CA-074 methyl ester inhibited osteoclastogenesis in vivo. [1] METHODS: To study the anti-inflammatory activity of CA-074 methyl ester, CVB+CA-074 methyl ester (4 mg/kg) was injected intramuscuarly into guinea pigs. RESULTS: Inflammation scores were significantly lower in the CVB+None group than in the CVB+ NONE group. The number of CD8+T cells was reduced in the CVB+CA-074 methyl ester group compared with the sham-operated group. [3]
StorageStore at low temperature Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.
Solubility Information10% DMSO+40% PEG300+5% Tween 80+45% Saline : 5 mg/mL (12.58 mM), Sonication is recommended.
DMSO : 257.5 mg/mL (647.85 mM), Sonication is recommended.
H2O : < 1 mg/mL (insoluble or slightly soluble)
Ethanol : 73 mg/mL (183.66 mM), Sonication is recommended.
KeywordsInhibitor | inhibit | CysteineProtease | Cysteine Protease | Cathepsin B | Cathepsin | CA-074 methyl ester | CA074 methyl ester | CA 074 methyl ester
Inhibitors RelatedPapain | 2-Aminoethanethiol | (S)-(+)-Ibuprofen | Asperphenamate | PMSF | JNJ-10311795 | N-Ethylmaleimide | Z-Lys-OH | Esomeprazole | 2-Cyanopyrimidine | Aloxistatin | 4-Methylesculetin
Related Compound LibrariesHighly Selective Inhibitor Library | Bioactive Compound Library | Anti-Neurodegenerative Disease Compound Library | Membrane Protein-targeted Compound Library | Protease Inhibitor Library | Inhibitor Library | Neuroprotective Compound Library | Immunology/Inflammation Compound Library | Anti-Aging Compound Library | Bioactive Compounds Library Max | Covalent Inhibitor Library | Anti-Cancer Active Compound Library

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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TargetMol Chemicals Inc.

6YR United StatesUnited States
  • Since: 2011-01-07
  • Address: 36 Washington Street, Wellesley Hill, MA
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