CAL-130 Hydrochloride NEW
| Price | $127 | $249 | $763 |
| Package | 2mg | 5mg | 25mg |
| Supply Ability: | 10g |
| Update Time: | 2026-05-11 |
Product Details
| Product Name: CAL-130 Hydrochloride | CAS No.: 1431697-78-7 |
| Supply Ability: 10g | Release date: 2026/05/11 |
Product Introduction
Bioactivity
| Name | CAL-130 Hydrochloride |
| Description | CAL-130 Hydrochloride is a PI3Kδ and PI3Kγ inhibitor (IC50s: 1.3 and 6.1 nM). |
| In vitro | CAL-130 selectively inhibits the catalytic domains of p110γ and p110δ with IC50s of 1.3 and 6.1 nM, respectively (115 and 56 nM for p110α and p110β), and does not affect other intracellular signaling pathways essential for cell function and survival, such as p38 MAPK or insulin receptor tyrosine kinase. |
| In vivo | The clinical significance of inhibiting PI3Kγ and PI3Kδ activities is assessed by administering CAL-130 to Lck/Ptenfl/fl mice with established T cell acute lymphoblastic leukemia. Candidate mice, exhibiting illness, a white blood cell count above 45,000/μL, blasts on peripheral smear, and >75% Thy1.2 and Ki-67 double-positive circulating cells, receive an oral dose (10 mg/kg) of CAL-130 every 8 hours for 7 days and are monitored until moribund. Despite the limited duration of therapy, CAL-130 effectively extends median survival to 45 days compared to 7.5 days for the control group. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 50 mg/mL (108.01 mM), Sonication is recommended. 10% DMSO+40% PEG300+5% Tween-80+45% Saline : 3.3 mg/mL (7.13 mM), Sonication is recommended. |
| Keywords | p110δ | p110γ | p110β | p110α | CAL-130 Hydrochloride | CAL130 Hydrochloride | CAL 130 Hydrochloride |
| Inhibitors Related | Musk ketone | Myricetin | Creatine monohydrate | Hyaluronic acid | 4-Methylbenzylidene camphor | 4-Vinylcyclohexene Dioxide | Berberine hydrogen sulphate | Isoprenaline hydrochloride | Quercitrin hydrate | Methyl eugenol | Quercetin | Berberine sulfate |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, USA
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