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Postion:Product Catalog >CTPI-2
CTPI-2
  • CTPI-2

CTPI-2 NEW

Price $40 $64
Package 50mg 100mg
Supply Ability: 10g
Update Time: 2026-06-01

Product Details

Product Name: CTPI-2 CAS No.: 68003-38-3
Purity: 97.91% Supply Ability: 10g
Release date: 2026/06/01

Product Introduction

Bioactivity

NameCTPI-2
DescriptionCTPI-2 is an inhibitor of mitochondrial citrate carrier SLC25A1 with(KD : 3.5 μM). CTPI-2 inhibits glycolysis, PPARγ, and its downstream target the glucose transporter GLUT4. CTPI-2 exhibits anti-tumor activity.CTPI-2 halts salient alterations of NASH reverting steatosis, preventing the evolution to steatohepatitis, reducing inflammatory macrophage infiltration in the liver and adipose tissue, and starkly mitigating obesity induced by a high-fat diet.
In vivoCTPI-2, halts salient alterations of NASH reverting steatosis, preventing the evolution to steatohepatitis, reducing inflammatory macrophage infiltration in the liver and adipose tissue, while starkly mitigating obesity induced by a high-fat diet.?These effects are differentially recapitulated by a global ablation of one copy of the Slc25a1 gene or by a liver-targeted Slc25a1 knockout, which unravel dose-dependent and tissue-specific functions of this protein.?Mechanistically, through citrate-dependent activities, Slc25a1 inhibition rewires the lipogenic program, blunts signaling from peroxisome proliferator-activated receptor gamma, a key regulator of glucose and lipid metabolism, and inhibits the expression of gluconeogenic genes.?The combination of these activities leads not only to inhibition of lipid anabolic processes, but also to a normalization of hyperglycemia and glucose intolerance as well[1].
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.
Solubility Information10% DMSO+40% PEG300+5% Tween 80+45% Saline : 10 mg/mL (28.03 mM), Suspension.
DMSO : 250 mg/mL (700.79 mM), Sonication is recommended.
10% DMSO+90% Saline : < 10 mg/mL (28.03 mM), Lower concentrations may be soluble, but exact solubility limit is unknown.
Keywordstransporter | steatosis | steatohepatitis | SLC25A1 | NSCLC | MitochondrialMetabolism | Mitochondrial Metabolism | mitochondrial | macrophage | Inhibitor | inhibit | inflammatory | glucose | CTPI-2 | CTPI2 | CTPI 2 | citrate | carrier
Inhibitors RelatedCiprofloxacin hydrochloride monohydrate | 1-Hexanol | Imeglimin hydrochloride | Rotenone | Glibenclamide | Permethrin | Ciprofloxacin monohydrochloride | (-)-Epigallocatechin Gallate | Phosphocreatine disodium | Sodium Molybdate | 4-Pentenoic acid | L-Histidine
Related Compound LibrariesCuproptosis Compound Library | Reprogramming Compound Library | Mitochondrial Membrane Protein-Targeted Compound Library | Bioactive Compound Library | Inhibitor Library | Mitochondria-Targeted Compound Library | NO PAINS Compound Library | Immunology/Inflammation Compound Library | Anti-Aging Compound Library | Bioactive Compounds Library Max | Anti-Cancer Compound Library | Anti-Cancer Active Compound Library

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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TargetMol Chemicals Inc.

6YR United StatesUnited States
  • Since: 2011-01-07
  • Address: 36 Washington Street, Wellesley Hill, MA
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