Etrasimod Impurity 13;392-83-6

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E-mail: anna@molcoo.com

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• Etrasimod Impurity 13

• Product Information

• Product Code: E063013

• English Name: Etrasimod Impurity 13

• English Alias: 1-bromo-2-(trifluoromethyl)benzene

• CAS No.：392-83-6

• Molecular Formula: C?H?BrF?

• Molecular Weight: 225.01

• Advantages

• Purity Assurance: HPLC ≥99.5%, confirmed by GC-MS and NMR.

• Stability: Stable for 36 months at room temperature, with <0.2% degradation in chloroform.

• Regulatory Compliance: Complies with USP/EP standards for halogenated impurities.

• Applications

• Residual Solvent Control: Quantifies brominated impurities in Etrasimod via GC-MS.

• Synthesis Monitoring: Tracks bromination side reactions during trifluoromethylbenzene synthesis.

• Method Validation: Validates GC methods for halogenated compound detection.

• Background Description

• This impurity is a potential residual brominating agent or by-product in Etrasimod synthesis. Halogenated impurities require strict control due to potential organ toxicity.

• Research Status

• Detection: GC-MS with DB-5MS column and EI source; LOD: 0.1 ppm.

• Formation: From excess bromine in trifluoromethylation steps; vacuum distillation reduces content by 90%.

• Toxicity: Acute toxicity studies show low oral LD50 in rats; chronic exposure data pending.

NOTE！

We can also customize related analogues and modified peptides including HPLC, MS, 1H-NMR, MS, HPLC, IR, UV, COA, MSDS.
This product is intended for laboratory use only!

WhatsAPP: +86 17320513646
E-mail: anna@molcoo.com

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