Etrasimod Impurity 15;1206125-14-5

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• Etrasimod Impurity 15

• Product Information

• Product Code: E063015

• English Name: Etrasimod Impurity 15

• English Alias: 1-cyclopentyl-2-(trifluoromethyl)benzene

• CAS No.：1206125-14-5

• Molecular Formula: C??H??F?

• Molecular Weight: 214.23

• Advantages

• High Purity: GC ≥99.0%, confirmed by NMR and IR spectroscopy.

• Stability: Shelf life of 24 months at 25℃, with <0.5% degradation in hexane.

• Regulatory Compliance: Meets FDA guidelines for organic impurities in drug products.

• Applications

• Impurity Detection: Used in GC-MS to quantify Impurity 15 in Etrasimod, ensuring ≤0.1% limit.

• Process Optimization: Monitors cyclopentyl substitution during benzene ring functionalization.

• Material Purity Control: Assesses raw material purity for trifluoromethylbenzene intermediates.

• Background Description

• This impurity originates from cyclopentylation of trifluoromethylbenzene, a key intermediate in Etrasimod synthesis. Controlling such aromatic impurities is vital for drug quality.

• Research Status

• Detection: GC with capillary column (DB-1701) and FID; LOD: 5 ppm.

• Formation Mechanism: Results from Friedel-Crafts alkylation side reactions; using selective catalysts reduces generation by 75%.

• Toxicity: In vitro studies show no genotoxicity; oral toxicity studies in mice ongoing

NOTE！

We can also customize related analogues and modified peptides including HPLC, MS, 1H-NMR, MS, HPLC, IR, UV, COA, MSDS.
This product is intended for laboratory use only!

WhatsAPP: +86 17320513646
E-mail: anna@molcoo.com

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