Etrasimod Impurity 17;567-15-7

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E-mail: anna@molcoo.com

• Etrasimod Impurity 17

• Product Information

• Product Code: E063017

• English Name: Etrasimod Impurity 17

• English Alias: 2,2'-bis(trifluoromethyl)-1,1'-biphenyl

• CAS No.：567-15-7

• Molecular Formula: C??H?F?

• Molecular Weight: 290.20

• Advantages

• Purity & Structure: HPLC ≥99.0%, confirmed by X-ray and HRMS.

• Stability: Stable for 36 months at -20℃, with <0.1% degradation in toluene.

• Regulatory Compliance: Supports ICH Q3C guidelines for residual solvent control.

• Applications

• Impurity Profiling: Detects biphenyl impurities in Etrasimod via HPLC/LC-MS.

• Synthesis Monitoring: Tracks biphenyl formation during trifluoromethylation coupling reactions.

• Environmental Risk Assessment: Evaluates potential ecological impact of halogenated biphenyls.

• Background Description

• This impurity forms from oxidative coupling of trifluoromethylbenzene intermediates. As a persistent organic pollutant, it requires strict control in pharmaceutical manufacturing.

• Research Status

• Detection: UPLC-MS/MS with C18 column and gradient elution; LOD: 0.005 ng/mL.

• Formation: Catalyzed by transition metals; using chelating agents reduces content by 85%.

• Toxicity: OECD tests show low aquatic toxicity, but bioaccumulation potential is being evaluated.

NOTE！

We can also customize related analogues and modified peptides including HPLC, MS, 1H-NMR, MS, HPLC, IR, UV, COA, MSDS.
This product is intended for laboratory use only!

WhatsAPP: +86 17320513646
E-mail: anna@molcoo.com

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