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Postion:Product Catalog >FT671
FT671
  • FT671

FT671 NEW

Price $488 $846 $1460
Package 25mg 50mg 100mg
Supply Ability: 10g
Update Time: 2026-05-11

Product Details

Product Name: FT671 CAS No.: 1959551-26-8
Purity: 99.76% Supply Ability: 10g
Release date: 2026/05/11

Product Introduction

Bioactivity

NameFT671
DescriptionFT671 is a non-covalent, selective USP7 inhibitor (IC50=52 nM) that binds to the catalytic domain of USP7 (Kd=7.8 μM). It disrupts the stability of USP7 substrates including MDM2, elevates p53, induces p21, and inhibits tumor growth in mice.
In vitroFT671 induces degradation of N-Myc protein and upregulation of p53 protein in the neuroblastoma cell line IMR-32. FT671 can elevate p53 protein levels in HCT116 colon carcinoma cells or the osteosarcoma (U2OS) cell line, thereby inducing the expression of p53 target genes, including BBC3 (encoding PUMA protein), CDKN1A (p21), RPS27L (S27L), and MDM2. FT671 also stabilizes p53 protein by enhancing MDM2 ubiquitination in the MM.1S multiple myeloma cell line, consequently promoting the expression of p53 target genes.
In vivoFT671 (100 mg/kg and 200 mg/kg, oral gavage, daily) demonstrated significant dose-dependent tumor growth inhibition in mice.
StorageStore at low temperature Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.
Solubility InformationDMSO : 25 mg/mL (46.86 mM), Sonication is recommended.
KeywordsUSP7 | FT671
Inhibitors RelatedP22074 | USP7-IN-4 | P 22077 | N-Ethylmaleimide | DUB-IN-1 | SJB3-019A | USP30 inhibitor 11 | Vialinin A | GRL0617 | Spautin-1 | USP8-IN-3 | 6-Thioguanine
Related Compound LibrariesBioactive Compound Library | Bioactive Compounds Library Max

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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