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Postion:Product Catalog >FT671
FT671
  • FT671

FT671 NEW

Price $2120 $2780 $3700
Package 25mg 50mg 100mg
Supply Ability: 10g
Update Time: 2025-07-17

Product Details

Product Name: FT671 CAS No.: 1959551-26-8
Supply Ability: 10g Release date: 2025/07/17

Product Introduction

Bioactivity

NameFT671
DescriptionFT671 is a non-covalent and selective inhibitor of USP7 (IC50: 52 nM) It also binds to the USP7 catalytic domain (Kd: 65 nM).
In vitroFT671 promotes the degradation of N-Myc and enhances p53 levels in the neuroblastoma cell line IMR-32, as well as in HCT116 and bone osteosarcoma (U2OS) cell lines. This results in the activation of p53 target genes, including BBC3 (which encodes PUMA), CDKN1A (p21), RPS27L (S27L), and MDM2. Additionally, in the MM.1S multiple myeloma cell line, FT671 stabilizes p53, associated with an upsurge in MDM2 ubiquitination. This stabilization of p53 triggers the expression of its target genes.
In vivoFT671 is well-to related even at high doses. FT671 (100 mg/kg and 200 mg/kg, oral gavage, daily) treatment in mice causes an obviously dose-dependent inhibition of tumor growth.
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility InformationDMSO : 50 mg/mL (93.72 mM), Sonication is recommended.
KeywordsUSP7 | FT-671 | FT671 | FT 671
Inhibitors RelatedP22074 | BAY 11-7082 | USP15-IN-1 | N-Ethylmaleimide | DUB-IN-1 | SJB3-019A | USP30 inhibitor 11 | Vialinin A | GRL0617 | Spautin-1 | 6-Thioguanine | USP8-IN-3

Company Profile Introduction

TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds. 170+ Compound Libraries, 10000+ Noval Small Molecucles,16000+ Nature Compounds TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.

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TargetMol Chemicals Inc.

2YR United StatesUnited States
  • Since: 2011-01-07
  • Address: 36 Washington Street, Wellesley Hill, Massachusetts, USA
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