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Postion:Product Catalog >Biochemical Engineering>Biochemical Reagents>Biological Dyes>Gallocyanine
Gallocyanine
  • Gallocyanine

Gallocyanine NEW

Price $30 $49
Package 5mg 10mg
Supply Ability: 10g
Update Time: 2026-04-22

Product Details

Product Name: Gallocyanine CAS No.: 1562-85-2
Supply Ability: 10g Release date: 2026/04/22

Product Introduction

Bioactivity

NameGallocyanine
DescriptionGallocyanine is a synthetic azine-based blue dye and a potent inhibitor of DKK1/LRP6 interaction (IC?? = 6.38 μM). It selectively activates the Wnt signaling pathway by blocking the binding of DKK1 to its receptor LRP6, thereby inhibiting the antagonistic effects of this pathway and inducing intracellular β-catenin accumulation. Gallocyanine exhibits antitumor metastasis, anti-inflammatory, and antifibrotic activities and can be used in research related to tumors, inflammatory injuries, and neurodegenerative diseases. Gallocyanine is a histological stain that specifically labels nucleic acids and cell nuclei; it can also serve as a biochemical fluorescent probe for the detection of superoxide anion radicals.
In vitroMethods: MDA-MB-231 and 4T1 cells were co-treated with BCSC-CM and gallocyanine at various concentrations (0–20 μM) for 48 hours. Cell viability was assessed, levels of reactive oxygen species (ROS) were measured using BODIPY-C11 staining, glutathione (GSH) levels were determined, and SLC7A11 protein expression levels were analyzed by Western blot. Results: Gallocyanine promoted the proliferation of breast cancer cells MDA-MB-231 and 4T1, inhibited lipid peroxidation, and increased GSH and SLC7A11 levels. [1] Methods: Primary AEC2 cells (overexpressing RAB6) were treated with 5 μM Gallocyanine for 48 hours. Western blot analysis was performed to detect β-catenin, SOX2, and nuclear β-catenin, and cell proliferation and colony-forming efficiency (CFE) were assessed. Results: Gallocyanine treatment significantly increased β-catenin and SOX2 protein expression, elevated nuclear β-catenin levels, and promoted the proliferation and clonogenic formation of RAB6-overexpressing AEC2 cells.[2]
In vivoMethods: To investigate the effect of Gallocyanine on lung metastasis following orthotopic transplantation, MDA-MB-231-luc cells were injected orthotopically into the mammary fat pad of BALB/c nude mice. Starting on the fourth day after tumor visibility, Gallocyanine (10 mg/kg) was administered intravenously every two days for four consecutive weeks. Results: Gallocyanine significantly reduced the lung metastasis burden, significantly decreased the size of metastatic lesions, and significantly prolonged the survival of the mice. [1] Methods: To investigate the therapeutic effects of Gallocyanine on PM2.5-induced pulmonary fibrosis, C57BL/6J mice were administered PM2.5 via intratracheal instillation (100 mg/kg, once weekly for 4 weeks) concurrently with Gallocyanine via intratracheal instillation (1 mg/kg, once weekly for 4 weeks). Results: Gallocyanine treatment significantly reduced PM2.5-induced collagen deposition in lung tissue, decreased hydroxyproline content in lung tissue, lowered α-SMA mRNA and protein levels, and reduced IL-1β and TNF-α levels in bronchoalveolar lavage fluid.[2]
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.
Solubility InformationDMSO : 74 mg/mL (219.76 mM), Sonication is recommended.
10% DMSO+40% PEG300+5% Tween-80+45% Saline : 1 mg/mL (2.97 mM), Sonication is recommended.
KeywordsGallocyanine
Inhibitors RelatedChlorquinaldol | Urea | Wnt pathway activator 1 | Neohesperidin | XAV-939 | Ethyl linoleate | Monensin sodium salt | Nimbolide | Isoquercetin | (±)-Nornicotine | Methyl Vanillate | Bisdemethoxycurcumin

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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TargetMol Chemicals Inc.

4YR United StatesUnited States
  • Since: 2011-01-07
  • Address: 36 Washington Street, Wellesley Hill, USA
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