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Postion:Product Catalog >Gboxin
Gboxin
  • Gboxin

Gboxin NEW

Price $37 $53 $85
Package 1mg 2mg 5mg
Supply Ability: 10g
Update Time: 2026-06-02

Product Details

Product Name: Gboxin CAS No.: 2101315-36-8
Purity: 99.96% Supply Ability: 10g
Release date: 2026/06/02

Product Introduction

Bioactivity

NameGboxin
DescriptionGboxin is an inhibitor of oxidative phosphorylation that targets glioblastoma,inhibits the activity of F0F1 ATP synthase, with antitumour activity.
In vitroGboxin, a small molecule that specifically inhibits the growth of primary mouse and human glioblastoma cells but not that of mouse embryonic fibroblasts or neonatal astrocytes.?Gboxin rapidly and irreversibly compromises oxygen consumption in glioblastoma cells.?Gboxin relies on its positive charge to associate with mitochondrial oxidative phosphorylation complexes in a manner that is dependent on the proton gradient of the inner mitochondrial membrane, and it inhibits the activity of F0F1 ATP synthase.?Gboxin-resistant cells require a functional mitochondrial permeability transition pore that regulates pH and thus impedes the accumulation of Gboxin in the mitochondrial matrix.?Administration of a metabolically stable Gboxin analogue inhibits glioblastoma allografts and patient-derived xenografts.?Gboxin toxicity extends to established human cancer cell lines of diverse organ origin, and shows that the increased proton gradient and pH in cancer cell mitochondria is a mode of action that can be targeted in the development of antitumour reagents.
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.
Solubility InformationH2O : 10 mg/mL (25.45 mM), Sonication is recommended.
10% DMSO+40% PEG300+5% Tween 80+45% Saline : 3 mg/mL (7.63 mM), Suspension.
DMSO : 30 mg/mL (76.34 mM), Sonication is recommended.
10% DMSO+90% Saline : 3.33 mg/mL (8.47 mM), Suspension.
KeywordsMitochondrialMetabolism | Mitochondrial Metabolism | Inhibitor | inhibit | Gboxin | F0F1?ATP synthase | F0F1 ATP synthase | ATP Synthase
Inhibitors RelatedCiprofloxacin hydrochloride monohydrate | Phenoxyethanol | 1-Hexanol | Imeglimin hydrochloride | Rotenone | Sodium oleate | (-)-Epigallocatechin Gallate | Sodium Molybdate | 4-Pentenoic acid | Revaprazan hydrochloride | 4'-Hydroxychalcone | L-Histidine
Related Compound LibrariesCuproptosis Compound Library | Glycometabolism Compound Library | Mitochondrial Membrane Protein-Targeted Compound Library | Bioactive Compound Library | Membrane Protein-targeted Compound Library | Inhibitor Library | Mitochondria-Targeted Compound Library | Anti-Aging Compound Library | Clinical Compound Library | Bioactive Compounds Library Max | Anti-Cancer Compound Library | Anti-Cancer Active Compound Library

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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6YR United StatesUnited States
  • Since: 2011-01-07
  • Address: 36 Washington Street, Wellesley Hill, MA
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