Idoxifene NEW
| Price | $1520 | $1980 | $2500 |
| Package | 25mg | 50mg | 100mg |
| Supply Ability: | 10g |
| Update Time: | 2025-07-30 |
Product Details
| Product Name: Idoxifene | CAS No.: 116057-75-1 |
| Supply Ability: 10g | Release date: 2025/07/30 |
Product Introduction
Bioactivity
| Name | Idoxifene |
| Description | Idoxifene is a tissue-specific selective estrogen receptor modulator. |
| In vitro | Idoxifene functions as an estrogen agonist in osteoblasts within the bone, while exhibiting minimal agonist activity in human endometrial cells. It, alongside E2, shields hepatocytes from damage caused by inflammatory cells through the inhibition of NF-κB, a proinflammatory transcription factor [2]. Additionally, Idoxifene safeguards vascular smooth muscle cells by mitigating the production of reactive oxygen species triggered by angiotensin II. It also notably reduces hepatic stellate cell (HSC) activation, curtails the proliferation of culture-activated HSCs in a dose-dependent manner, and promotes the apoptosis of these cells over time [1]. |
| In vivo | Idoxifene at doses of over 0.1 mg/kg significantly reduces the hepatic levels of collagen and MDA in the DMN model in a dose-dependent manner. Animals receive daily intraperitoneal injections of Estradiol (0.5 mg/kg) and an oral gavage of Idoxifene (0.02, 0.1, and 0.5 mg/kg) for 3 days after Dimethylnitrosamine (DMN) treatment. Although Idoxifene and E2 are administered by different routes, i.e., by oral ingestion and intraperitoneal injection, respectively. However, the antifibrotic effect of a dose of 0.5 mg/kg of Idoxifene is somewhat greater than that of the same dose of E2 [2]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Keywords | Idoxifene | Estrogen receptor | CB-7432 | CB 7432 |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
You may like
Recommended supplier
| Product name | Price | Suppliers | Update time | |
|---|---|---|---|---|
| $619.00 |
VIP4Y
|
TargetMol Chemicals Inc.
|
2026-04-22 | |
| $1.10 |
VIP6Y
|
Dideu Industries Group Limited
|
2025-11-18 | |
|
VIP7Y
|
Shaanxi Dideu Medichem Co. Ltd
|
2020-04-30 |
United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, Massachusetts, USA
INQUIRY