Manufacturer Provide Pharmaceutical Grade Raw Material CAS53-86-1 Indomethacin

Introduction

Product Name:   Indomethacin

Other Name :1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-ylacetic acid;indomethacin crystalline

C.A.S NO. :53-86-1

Assay (%)(HPLC, Basis on drying):99%

Appearance: White Crystals Powder

MF:C19H16ClNO4

MW:357.79

Melting Point :158-162 °C (dec.)(lit.)

Boiling Point :499.4±45.0 °C(Predicted)

Density:1.2135g/cm3

Storage Condition: Store in cool and dry places ,keep away from strong light 

Indomethacin, an anti-inflammatory agent, inhibits Cox-1 and Cox-2 (cyclooxygenases) with selectivity for Cox-1 (IC50 of 230 nM) over Cox-2 (IC50 of 630 nM). Additionally, indomethacin displays adipogenic actions via binding and activation of PPARγ (peroxisome proliferator-activated receptor γ), a ligand-activated transcription factor known to play an important role in adipogenesis. Other studies show indomethacin to stabilize cholesterol-dependent nanoclusters and enhance phase separation in biological membranes, which could consequentially effect plasma membrane assembled cell signaling cascades. Indomethacin is an activator of PPAR α.