Product Details
| Product Name:
JC2-11 |
CAS No.:
937820-89-8 |
| Purity:
99.88% |
Supply Ability:
10g |
| Release date:
2026/05/06 |
Product Introduction
Bioactivity
| Name | JC2-11 |
| Description | JC2-11 is an inhibitory compound for inflammation.JC2-11 inhibits the recruitment domain-containing proteins NLRC 4, atypical in melanoma 2 (AIM 2) and atypical (NC) inflammatory vesicles by disrupting reactive oxygen species (ROS) production and caspase-1 activity.JC2-11 reduces caspase-1 (p20) secretion, gasdermin D (GSDMD) cleavage, IL-1β and lactate dehydrogenase (LDH) activity in inflammatory vesicles. JC2-11 reduced caspase-1 (p20) secretion, gasdermin D (GSDMD) cleavage, IL-1β and lactate dehydrogenase (LDH) release from inflammatory vesicles. |
| In vivo | JC2-11 (250 μg/mouse; i.p.; single dose) significantly inhibited the release of caspase-1 (p20) and IL-1β from the non-canonical (NC) inflammasome in the C57BL/6 mouse model, attenuated NC inflammasome activation.[1] |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 127.5 mg/mL (421.77 mM), Sonication is recommended.
|
| Keywords | ROS | NODlikeReceptor(NLR) | NODlikeReceptor | NOD-like Receptor (NLR) | NODlike Receptor (NLR) | NOD-like Receptor | NLR | LDH | JC2-11 | JC211 | ILReceptor | IL-1β | IL Receptor | Caspase-1 | AIM2 |
| Inhibitors Related | Ethoxyquin | Kaolin | Stavudine | Allopurinol | Imeglimin hydrochloride | Ethyl linoleate | Magnesium acetate tetrahydrate | Inosine | L-Cystine | Cystamine dihydrochloride | L-Ascorbic acid sodium salt | Dimethyl phthalate |
| Related Compound Libraries | Apoptosis Compound Library | Glycometabolism Compound Library | Bioactive Compound Library | Cytokine Inhibitor Library | Membrane Protein-targeted Compound Library | HIF-1 Signaling Pathway Compound Library | Protease Inhibitor Library | Metabolism Compound Library | Anti-Aging Compound Library | Immunology/Inflammation Compound Library | Bioactive Compounds Library Max | Fluorochemical Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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