ML-180 NEW
| Price | $70 | $116 | $218 |
| Package | 5mg | 10mg | 25mg |
| Supply Ability: | 10g |
| Update Time: | 2026-05-26 |
Product Details
| Product Name: ML-180 | CAS No.: 863588-32-3 |
| Purity: 99.83% | Supply Ability: 10g |
| Release date: 2026/05/26 |
Product Introduction
Bioactivity
| Name | ML-180 |
| Description | ML-180 (SR1848) is a potent inverse agonist of the orphan nuclear receptor liver receptor homolog 1 (LRH-1; NR5A2) with an IC50 of 3.7 μM. |
| In vitro | ML-180 (0.5-5 μM; 24 hours) shows a significant inhibition of cyclin-D1 and cyclin-E1 expression in hepatic cells, but has little effect on repression in SK-OV-3 cells[2]. ML-180 (5 μM; 24 hours) leads to a rapid decrease of LRH-1 expression and efficiently represses endogenous LRH-1 signaling[2]. |
| In vivo | ML-180 has a statistically significant decrease of both LRH-1 and SHP mRNA in adrenal glands and pancreatic tissue[2]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 19.5 mg/mL (50.14 mM), Sonication is recommended. |
| Keywords | steroidogenic | SR-1848 | SR 1848 | SF-1 | receptor | orphan nuclear receptor NR5A2 | Orphan | nuclear | NR5A2 | NR5A1 | ML-180 | ML180 | ML 180 | LRH-1 | liver | Inhibitor | inhibit | homolog | factor-1 | cancers |
| Inhibitors Related | NR2F6 modulator-2 | TS-011 | LRH-1 Inhibitor-3 | SID 7969543 | CIA-1 (Free base) | NR2E3 agonist 1 | CID 1375606 | AF64394 | RJW100 | DLPC | ML179 | BI-6015 |
| Related Compound Libraries | Bioactive Compound Library | NO PAINS Compound Library | Bioactive Compounds Library Max | GPCR Compound Library | Anti-Cancer Compound Library | Anti-Cancer Active Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, MA
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