Nicotinamide NEW
| Price | $29 |
| Package | 1mL |
| Supply Ability: | 10g |
| Update Time: | 2026-05-12 |
Product Details
| Product Name: Nicotinamide | CAS No.: 98-92-0 |
| Purity: 99.86% | Supply Ability: 10g |
| Release date: 2026/05/12 |
Product Introduction
Bioactivity
| Name | Nicotinamide |
| Description | Nicotinamide, a vitamin B3 derivative, is an inhibitor of SIRT1 (IC50=50-180 μM) and SIRT2 (IC50=2 μM). Nicotinamide can be used as a precursor of nicotinamide adenine dinucleotide or NAD+, which can be supplemented by dietary intake and can prevent or treat melanoglossia and pellagra. |
| In vitro | METHODS: A375, SK-MEL-28, and mouse B16-F10 cells were treated with Nicotinamide (0, 1, 20, and 50 mM) for 24 or 48 hours. RESULTS: Nicotinamide reduced cell numbers ina dose-dependent manner, with a strong inhibitory effect at 20mM and almost full effect at 50mM. [1] |
| In vivo | METHODS: To study the anti-tumor activity of Nicotinamide, mice were intraperitoneally injected with Nicotinamide (1500 and 1800 mg/Kg, 5 days a week). RESULTS: Nicotinamide inhibited tumor growth ina mouse model of metastatic melanoma. [1] METHODS: To study the antiviral activity of Nicotinamide, Nicotinamide (0-200 mg/kg, 5 days) was intraperitoneally injected into HBV transgenic mice. RESULTS: Nicotinamide inhibited HBV replication in HBV transgenic mice. [2] |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 260 mg/mL (2129.05 mM), Sonication is recommended. Saline : 50 mg/mL (409.43 mM), Solution. 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 5 mg/mL (40.94 mM), Sonication is recommended. H2O : 122.7 mg/mL (1004.75 mM), Sonication is recommended. Ethanol : 23 mg/mL (188.34 mM), Sonication is recommended. |
| Keywords | skin cancer | Sirtuin | SIRT | Nicotinamide | Murine metastatic melanoma model | Melanoma | Inhibitor | inhibit | EndogenousMetabolite | Endogenous Metabolite | A375 cell |
| Inhibitors Related | Sucrose | Aceglutamide | Nicotinamide riboside malate | D(+)-Raffinose pentahydrate | Guanidine hydrochloride | Malic acid | Formamide | Glycerol | Thymidine | Corn starch | Gluconate Calcium | DL-Lysine |
| Related Compound Libraries | Traditional Chinese Medicine Monomer Library | Bioactive Compound Library | Drug Repurposing Compound Library | Anti-Viral Compound Library | Natural Product Library | Tobacco Monomer Library | Natural Product Library for HTS | FDA-Approved Drug Library | Anti-virus Traditional Chinese Medicine Monomer Library | Bioactive Compounds Library Max | Gut Microbial Metabolite Library | Food as Medicine Compound Library |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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