Product Details
| Product Name:
NMDI14 |
CAS No.:
307519-88-6 |
| Purity:
99.37% |
Supply Ability:
10g |
| Release date:
2026/05/26 |
Product Introduction
Bioactivity
| Name | NMDI14 |
| Description | NMDI14 is a highly specific, small-molecule, non-competitive inhibitor of the nonsense-mediated RNA decay (NMD) pathway with an IC?? value of 1.8 μM. NMDI14 can be used for studying NMD pathway function, PTC-related genetic disorders, and tumor research. |
| In vitro | Methods: Human CRC cells: DLD1, RKO (MSI-H); SW480, SW620 (MSS) were treated with NMDI14 (10 μM) for 24 h. mRNA levels of classic NMD target genes (BAG1, GAS5, ATF4) were detected by qRT-PCR.
Results: NMDI14 treatment significantly upregulated NMD target gene expression in all tested cell lines, confirming its effective inhibition of NMD. [1] |
| In vivo | Methods: MC38 cells were subcutaneously inoculated into C57BL/6J mice. Following successful inoculation, NMDI14 (10 mg/kg) was administered via intraperitoneal injection every other day for 23 days. Tumor volume and weight were monitored, and tumor-infiltrating immune cells were analyzed by flow cytometry.
Results: In C57BL/6J mice, NMDI14 significantly inhibited tumor growth and increased CD8? T cell, DC, and NK cell infiltration along with IFN-γ levels.[1] |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : < 1 mg/mL (insoluble), Sonication is recommended.
|
| Keywords | NMDI-14 | NMDI14 | NMDI 14 | NMD | Inhibitor | inhibit |
| Inhibitors Related | 5-Fluorouracil | Adenine hemisulfate | Erythromycin thiocyanate | Guanidine hydrochloride | Hexane-1,6-diol | 1,4-Naphthoquinone | Adenine | Vidarabine | Carbazole | Thymidine | Docosanoic acid | Usnic Acid |
| Related Compound Libraries | DNA Damage & Repair Compound Library | Bioactive Compound Library | Inhibitor Library | NO PAINS Compound Library | Bioactive Compounds Library Max |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
Recommended supplier
| Product name |
Price |
|
Suppliers |
Update time |
|
|
$32.00
|
VIP4Y
|
TargetMol Chemicals Inc.
|
2026-05-26 |
United States