Novobiocin NEW
| Price | $53 | $77 | $126 |
| Package | 5mg | 10mg | 25mg |
| Supply Ability: | 10g |
| Update Time: | 2026-07-15 |
Product Details
| Product Name: Novobiocin | CAS No.: 303-81-1 |
| Purity: 99.19% | Supply Ability: 10g |
| Release date: 2026/07/15 |
Product Introduction
Bioactivity
| Name | Novobiocin |
| Description | Novobiocin is an orally active and potent antibiotic.Novobiocin is a DNA gyrase inhibitor and heat shock protein 90 (Hsp90) antagonist with inhibitory effects on gyrase and Hsp90. Novobiocin has anti-positive activity and can be used to study highly resistant pneumococcal infections. |
| In vitro | Novobiocin (1 mM) competitively hinders the binding of ATP to gyrase B, disrupting nucleotide binding, and impairs the interaction between the co-chaperones Hsc70 and p23 with Hsp90.[1] Novobiocin (200 μM; 24 h) results in the inhibition of the repair rate of DNA interstrand cross-links induced by both cisplatin (cis-DDP) and BCNU. This is accompanied by a corresponding reduction in the clonogenic survival of human glioblastoma multiforme cells.[2] Novobiocin (0.3 mM; 48 hours) triggers caspase-3/7 enzyme-dependent apoptosis assays, resulting in an approximate three- to fivefold increase in the number of apoptotic cells in K562, HL60, and Mutz-2.[5] |
| In vivo | Novobiocin (25, 50, 100, 200 mg/kg; s.c.; 4 times at 1, 5, 24, and 48 h after infection; Adult female Swiss mice (30g) with sepsis induced by the penicillin-susceptible strain (AR33118)) exhibits anti-infection activity in mice infected with amoxicillin-resistant Streptococcus pneumoniae.[3] |
| Storage | Store at low temperature,Keep away from moisture, Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 237.5 mg/mL (387.68 mM), Sonication is recommended. 10% DMSO+40% PEG300+5% Tween-80+45% Saline : 5 mg/mL (8.16 mM), Sonication is recommended. |
| Keywords | VirusProtease | Virus Protease | Orthopoxvirus | Novobiocin | HSP90 | DNAgyrase | DNA gyrase | Bacterial | Apoptosis | Antibiotic |
| Inhibitors Related | Neomycin sulfate | Aceglutamide | D(+)-Raffinose pentahydrate | Guanidine hydrochloride | Sulfamethoxazole sodium | Terbinafine hydrochloride | Formamide | Thymidine | Hyaluronic acid sodium (MW 20 kDa) | Dimethyl sulfoxide | Sodium diacetate | Sodium bicarbonate |
| Related Compound Libraries | Membrane Protein-targeted Compound Library | Anti-Cancer Clinical Compound Library | Natural Product Library | Microbial Natural Product Library | Inhibitor Library | FDA-Approved Drug Library | Natural Product Library for HTS | Anti-infective Natural Product Library | Anti-Aging Compound Library | Immunology/Inflammation Compound Library | Bioactive Compounds Library Max | Anti-Cancer Active Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
You may like
Recommended supplier
| Product name | Price | Suppliers | Update time | |
|---|---|---|---|---|
| $40.00 |
VIP4Y
|
TargetMol Chemicals Inc.
|
2026-07-15 | |
| $40.00 |
VIP2Y
|
TargetMol Chemicals Inc.
|
2026-07-15 | |
|
VIP1Y
|
Hefei Lbao Physical & Chemical Science Co.,Ltd
|
2026-05-18 | ||
| $48.00 |
Guangzhou Sunton Biotechnology Co., Ltd.
|
2023-05-04 | ||
| $1.00 |
VIP7Y
|
Career Henan Chemical Co
|
2019-12-26 |
United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, MA
INQUIRY