Product Details
| Product Name:
P163-0892 |
CAS No.:
1574576-45-6 |
| Supply Ability:
10g |
Release date:
2026/05/11 |
Product Introduction
Bioactivity
| Name | P163-0892 |
| Description | P163-0892 is a highly effective and specific antifungal compound targeting Cryptococcus species. Additionally, P163-0892 demonstrates moderate capability to penetrate the blood-brain barrier [1]. |
| In vitro | P163-0892, at concentrations ranging from 0-32 μg/mL over 48 hours, demonstrates antifungal efficacy, achieving minimum inhibitory concentrations (MICs) of 0.25 μg/mL and 0.5 μg/mL against Cryptococcus neoformans and Cryptococcus gattii, respectively. Notably, it also exhibits favorable aqueous solubility and is devoid of cytotoxic and significant cardiotoxic effects. |
| In vivo | P163-0892 (10 mg/kg; 5 days) significantly extends the survival of larvae infected with either C. neoformans or C. gattii [1]. Animal Model: Wax moth larva infected with C. neoformans H99 or C. gattii WM178 [1]. Dosage: 10 mg/kg. Administration: 5 days. Result: Increased survival rate of larvae. Animal Model: Male Sprague–Dawley rats (200–250 g) [1]. Dosage: 2 mg/kg or 5 mg/kg. Administration: Intravenous or oral (Pharmacokinetic Analysis). Result: Pharmacokinetic Parameters of P163-0892: iv 2 mg/kg: C0 2460 ng/mL, Cmax 7.61 ng/mL, T1/2 749 h, Tmax 172 h, AUC0-inf 2.63 (h ng/mL), Cl 7.12 (mL/h/kg), MRT0-t 3.17 h, Vdss (L/kg) 7.12, BA (%) po 5 mg/kg: C0 2.97 ng/mL, Cmax 15.3 ng/mL, T1/2 3.17 h, NR. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Shipping with blue ice/Shipping at ambient temperature. |
| Inhibitors Related | Calcium Propionate | Dehydroacetic acid sodium | Potassium gluconate | D-Gluconic acid (solution) (50% in H2O) | Sulfacetamide sodium | Terbinafine hydrochloride | Benzyl propionate | Sodium formate | Magnesium acetate tetrahydrate | Geraniol | L-Citronellol | Benzimidazole |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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