PF-592379 NEW
| Price | $1520 | $1980 | $2500 |
| Package | 25mg | 50mg | 100mg |
| Supply Ability: | 10g |
| Update Time: | 2025-07-18 |
Product Details
| Product Name: PF-592379 | CAS No.: 710655-15-5 |
| Supply Ability: 10g | Release date: 2025/07/18 |
Product Introduction
Bioactivity
| Name | PF-592379 |
| Description | PF-592379 is a potent agonist of dopamine D3 receptor (EC50: 21 nM). |
| In vitro | PF-592379 is a potent and selective dopamine 3 agonist with an Emax of 95% compared to Pramipexole [1]. It exhibits an EC50 of 21 nM and Ki of 322 nM [2], showing high affinity to human D3 receptors (Ki=215 nM) and a 19-fold selectivity over D4 receptors (Ki=4165 nM). PF-592379 does not bind to D1, human D2, or D5 receptors at concentrations up to 10 μM (Ki≥10 μM) [3]. |
| In vivo | PF-592379 acts as an oral dopamine 3 agonist in rats and dogs. It exhibits a clearance rate of 6.3 and 8.5 mL/min/kg in dogs and 44.8 and 58.2 mL/min/kg in rats, considered low to moderate relative to liver blood flow. The compound demonstrates high permeability in Caco-2 cells and shows complete absorption in pharmacokinetic studies carried out on rats and dogs, achieving oral bioavailability rates of 28% in rats and 61 to 87% in dogs [1]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Keywords | PF-592379 | PF592379 | PF 592379 | D3 receptor |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, Massachusetts, USA
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