PSN-GK1 NEW
| Price | $1520 | $1980 | $2500 |
| Package | 25mg | 50mg | 100mg |
| Supply Ability: | 10g |
| Update Time: | 2026-04-20 |
Product Details
| Product Name: PSN-GK1 | CAS No.: 745051-61-0 |
| Supply Ability: 10g | Release date: 2026/04/20 |
Product Introduction
Bioactivity
| Name | PSN-GK1 |
| Description | PSN-GK1 is a potent activator of glucokinase (EC50: 0.13 μM). |
| In vivo | PSN-GK1 demonstrates an excellent pharmacokinetic profile with high oral bioavailability in rats and significantly reduces blood glucose levels, showing potent antihyperglycemic effects in diabetic rodents without causing hypoglycemia [1]. At 5 mM glucose, PSN-GK1 activates glucokinase (4.3-fold, EC50: 130 nM), increases MIN6 insulin secretion (26-fold, EC50: 267 nM), and enhances 2-DG hepatocytic uptake (3-fold, EC50: 1 μM). In C57Bl/6 mice, PSN-GK1 reduces blood glucose at 1 and 10 mg/kg orally, with significant insulin increase only at the higher dose. In hyperinsulinemic 10-mM glucose clamps, PSN-GK1 increases 2-DG incorporation into liver glycogen sixfold [2]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| Keywords | PSN-GK-1 | PSN-GK1 | PSNGK1 | PSN GK1 |
| Inhibitors Related | Gcase activator 2 | ARRY-403 | ML251 | PFK-015 | PFKFB3-IN-2 | D-(-)-3-Phosphoglyceric acid disodium | Oxfendazole | AZ PFKFB3 26 | AMG-1694 | RO-28-1675 | Dorzagliatin | PF-04937319 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
You may like
Recommended supplier
| Product name | Price | Suppliers | Update time | |
|---|---|---|---|---|
| $35.00 |
VIP6Y
|
TargetMol Chemicals Inc.
|
2026-05-11 | |
| $1980.00 |
VIP2Y
|
TargetMol Chemicals Inc.
|
2025-07-17 |
United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, USA
INQUIRY